摘要
生酮饮食是一种高脂肪、低碳水化合物、蛋白质及其他营养素以适宜比例构成为特点的饮食方式。目前,生酮饮食在难治性癫痫的治疗中可发挥重要的作用。最新研究发现生酮饮食不仅可以减轻新型冠状病毒肺炎患者的症状,而且可以有效控制肥胖或糖尿病患者的血糖水平及体质量。在肿瘤治疗中,生酮饮食既可以直接发挥抑癌效应,也可以增强其他抗癌治疗方法的效果。然而,也有研究质疑生酮饮食的临床效果,并提出长期的生酮饮食可能增加肿瘤(例如结直肠癌)、心血管疾病及代谢异常的发生风险。本研究对生酮饮食在疾病治疗中的研究进展进行综述,以期为客观评价其临床价值以及优化生酮饮食临床应用提供新的思路。
Ketogenic diet is a diet type characterized by high fat, low carbohydrate, protein and other nutrients in an appropriate proportion. At present, ketogenic diet plays an important role in the treatment of intractable epilepsy. The latest research found that ketogenic diet can not only alleviate the symptoms of patients with Coronavirus Disease 2019, but also effectively control the blood glucose level and body mass of patients with obesity or diabetes. In the treatment of cancer, ketogenic diet can not only directly play a role in tumor inhibition, but also enhance the effect of other anti-cancer treatment. However, some studies had questioned the clinical effect of ketogenic diet, and proposed that long-term ketogenic diet may increase the incidence risks of tumors(such as colorectal cancer), cardiovascular diseases and metabolic abnormalities. This study reviewed the research progress of ketogenic diet in treating diseases in order to provide a new idea for objectively evaluating clinical value and optimizing the clinical application of ketogenic diet.
作者
朱思源
王安东
严雪冰
ZHU Siyuan;WANG Andong;YAN Xuebing(Department of Oncology,Affiliated Hospital of Yangzhou University,Yangzhou,Jiangsu,225001;Yangzhou University,Yangzhou,Jiangsu,225009)
出处
《实用临床医药杂志》
CAS
2022年第20期142-148,共7页
Journal of Clinical Medicine in Practice
基金
国家自然科学基金资助项目(81902422)
江苏省卫生健康委面上项目(M2020024)
江苏省科协青年科技人才托举工程项目(TJ-2022-022)
江苏省扬州市重点研发项目(社会发展)(YZ2020078)
江苏省高等学校大学生创新创业训练计划项目(202111117026Z)
关键词
生酮饮食
癫痫
新型冠状病毒肺炎
代谢性疾病
肿瘤
肠道菌群
ketogenic diet
epilepsy
Coronavirus Disease 2019
metabolic diseases
tumors
intestinal flora
