摘要
调节性T淋巴细胞(Treg)和辅助性T淋巴细胞17(Th17)在肝细胞癌(HCC)的肿瘤微环境中发挥重要作用,Treg/Th17失衡与HCC的侵袭和进展密切相关。同时,细胞因子信号传导抑制因子1(SOCS1)作为Janus激酶/信号转导和转录激活因子信号通路的负调控因子之一,参与调控Treg细胞和Th17细胞的增殖、分化。本文主要分析HCC中SOCS1与Treg/Th17平衡的关系,探究HCC发生发展过程中的免疫相关机制。
The regulatory T cells(Treg)and helper T cells 17(Th17)play an important role in regulation of the tumor microenvironment in hepatocellular carcinoma(HCC)because Treg/Th17 imbalance was associated with HCC cell invasion and progression.Moreover,the suppressor of cytokine signaling 1(SOCS1),a negative regulator of the Janus kinase(JAK)/signal transducers and activators of transcription(STAT)pathway,regulates Treg and Th17 proliferation and differentiation.This review summarized and discussed the recent advancement and progress in control of the Treg/Th17 balance in HCC and the immunity-related mechanisms in HCC development and progression,i.e.,the SOCS1 structure and functions,SOCS1 role in regulation of Treg/Th17 balance in HCC,and future research direction of the field.
作者
宋瑞
李静
杨红菊
李敏玥
游晶
SONG Rui;LI Jing;YANG Hongju;LI Minyue;YOU Jing(The NHC Key Laboratory of Drug Addiction Medicine,Department of Geriatric Gastroenterology,The First Affiliated Hospital of Kunming Medical University,Kunming 650032,China;School of Public Health,Kunming Medical University,Kunming 650500,China)
出处
《临床肝胆病杂志》
CAS
北大核心
2022年第11期2627-2631,共5页
Journal of Clinical Hepatology
基金
国家自然科学基金(81760111,81760617)
国家卫生健康委员会毒品依赖和戒治重点实验室科学研究A类重点项目(2020DAMARA-003)。
关键词
癌
肝细胞
细胞因子类
信号传导
T淋巴细胞
调节性
T淋巴细胞
辅助诱导
Carcinoma,Hepatocellular
Cytokines
Signal Transduction
T-Lymphocytes,Regulatory
T-Lymphocytes,Helper-Inducer
