摘要
目的分析胃癌前病变患者幽门螺杆菌(helicobacter pylori)感染患者的危险因素及与胃癌指标水平的相关性,为预防Hp感染提供理论依据。方法选2019年1月至2022年1月来徐州市第一人民医院治疗的胃癌前病变患者239例,采用尿毒[^(13)C]片呼气试验药盒测定Hp感染情况,根据HP感染感染情况分为Hp组(n=64)和正常组(n=175),根据DOB值判断Hp感染程度分为Hp(+)、Hp(++)、Hp(+++);统计所有研究对象年龄、性别、饮食结构、经常在外进餐、饮酒、经常进食腌制食品、家族胃癌史、地域性、受教育程度等情况;采用logistics回归分析居民发生Hp感染的独立危险因素;测定血清G-17、PGI/PGII、CA72-4水平,对HP感染与血清G-17、PGI/PGII、CA72-4水平进行Pearson相关性分析;结果Hp组血清G-17、CA72-4水平显著高于正常组(P<0.05);Hp组血清PGI/PGII水平显著低于正常组(P<0.05);Hp(+++)组血清G-17、CA72-4水平显著高于Hp(++)组和Hp(+)组(P<0.05);Hp(+++)组血清PGI/PGII水平显著低于Hp(++)组和Hp(+)组(P<0.05);两组在嗜辣、地域性、经常在外进餐、饮酒、经常进食腌制食品、家族胃癌史等方面进行比较,差异有统计学意义(P<0.05);经常进食腌制食品、嗜辣、家族胃癌史是发生Hp感染的独立危险因素(P<0.05);经Pearson相关性分析,Hp感染与血清G-17、CA72-4水平呈正相关(r=0.439,0.451,P<0.05);Hp感染与PGI/PGII水平呈负相关(r=-0.472,P<0.05)。结论胃癌前病变Hp感染与血清G-17、PGI/PGII、CA72-4水平具有明显相关性,应重视Hp感染的根治治疗,定期监测胃癌指标变化,预防胃癌的发生。
Objective To analyze the risk factors of helicobacter pylori(Hp)infection in patients with precancerous lesions of gastric cancer and their correlation with gastric cancer index levels,providing theoretical basis for the prevention of Hp infection.Methods The 239 suspected CASES of Hp infection treated in hospital from January 2019 to January 2022 were tested for Hp infection by urinaltoxin[^(13)C]tablets breath test cartridge.According to Hp infection,they were divided into Hp group(n=64)and normal group(n=175).The degree of Hp infection was divided into Hp(+)and Hp(++)according to DOB value.,Hp(+++);Age,sex,diet structure,eating out frequently,drinking alcohol,eating preserved food frequently,family history of gastric cancer,region,education level,etc.Logistic regression was used to analyze the independent risk factors of HP infection among residents.Serum G-17,PGI/PGII and CA72-4 levels were determined.Pearson correlation analysis was conducted between HP infection and serum G-17,PGI/PGII and CA72-4 levels.Results The serum levels of G-17 and CA72-4 in Hp group were significantly higher than those in normal group(P<0.05).The level of serum PGI/PGII in Hp group was significantly lower than that in normal group(P<0.05).The serum levels of G-17 and CA72-4 in Hp(+++)group were significantly higher than those in Hp(++)group and Hp(+)group(P<0.05).The level of serum PGI/PGII in Hp(+++)group was significantly lower than that in Hp(++)and Hp(+)groups(P<0.05);There were statistically significant differences between the two groups in spicy,regional,drinking,often eating preserved food and family history of gastric cancer(P<0.05).Eating salted food frequently,being addicted to spicy food and family history of gastric cancer were independent risk factors for HP infection(P<0.05).Pearson correlation analysis showed that Hp infection was positively correlated with serum G-17 and CA72-4 levels(r=0.439,0.451,P<0.05).Hp infection was negatively correlated with PGI/PGII level(r=-0.472,P<0.05).Conclusion There is a significant correlation between Hp infection and serum G-17,PGI/PGII and CA72-4 levels in precancerous lesions of gastric cancer.Radical treatment of Hp infection should be emphasized,and the changes of gastric cancer indicators should be monitored regularly to prevent the occurrence of gastric cancer.
作者
赵茜
彭辉
ZHAO Qian;PENG Hui(Department of Laboratory,Xuzhou First People′s Hospital,Xuzhou,Jiangsu 221000,China)
出处
《公共卫生与预防医学》
2022年第6期128-131,共4页
Journal of Public Health and Preventive Medicine
关键词
胃癌前病变
幽门螺杆菌感染
胃癌指标
Gastric precancerous lesions
Helicobacter pylori infection
Gastric cancer index
