摘要
目的 探讨难治性结核性脑膜炎患者选用莫西沙星联合抗结核药物治疗的效果。方法 50例难治性结核性脑膜炎患者,按1∶1比例分为观察组与对照组,各25例。对照组选用抗结核药物治疗,观察组在对照组基础上联合莫西沙星治疗。比较两组临床疗效、不良反应发生情况及治疗前后相关临床指标。结果 观察组治疗总有效率为96.00%,高于对照组的72.00%,差异有统计学意义(P<0.05)。观察组不良反应发生率为20.00%,与对照组的16.00%比较,差异无统计学意义(P>0.05)。治疗后,观察组颅内压力(135.58±28.41)mm H_(2)O(1 mm H_(2)O=0.0098 kPa)、蛋白质(0.52±0.11)g/L、白细胞计数(7.41±1.08)×10^(9)/L、神经生长因子(NGF)(16.41±3.58)ng/L低于对照组的(186.25±32.11)mm H_(2)O、(0.92±0.32)g/L、(93.62±20.14)×10^(9)/L、(27.52±5.14)ng/L,氯化物(128.74±4.52)mmol/L、葡萄糖(2.91±1.02)mmol/L高于对照组的(105.75±2.61)、(2.15±0.72)mmol/L,差异有统计学意义(P<0.05)。结论 莫西沙星联合抗结核药物在难治性结核性脑膜炎治疗中效果确切,值得借鉴。
Objective To discuss the effect of moxifloxacin combined with antituberculous drugs in the treatment of refractory tuberculous meningitis.Methods A total of 50 patients with refractory tuberculous meningitis were divided into observation group and control group according to the ratio of 1∶1,with 25 cases in each group.The control group was treated with anti-tuberculosis drugs,and the observation group was treated with moxifloxacin on the basis of the control group.The clinical efficacy,occurrence of adverse reactions,and related clinical indicators before and after treatment were compared between the two groups.Results The total effective rate of the observation group was 96.00%,which was higher than 72.00%of the control group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions in the observation group was 20.00%,and the difference was not statistically significant compared with 16.00%in the control group(P>0.05).After treatment,the intracranial pressure(135.58±28.41)mm H2O(1 mm H2O=0.0098 kPa),protein(0.52±0.11)g/L,white blood cell count(7.41±1.08)×10^(9)/L,nerve growth factor(NGF)(16.41±3.58)ng/L of the observation group were lower than(186.25±32.11)mm H2O,(0.92±0.32)g/L,(93.62±20.14)×10^(9)/L,(27.52±5.14)ng/L of the control group;the chloride(128.74±4.52)mmol/L and glucose(2.91±1.02)mmol/L were higher than(105.75±2.61)and(2.15±0.72)mmol/L of the control group;the differences were all statistically significant(P<0.05).Conclusion Moxifloxacin combined with antituberculous drugs has definite effect in the treatment of refractory tuberculous meningitis,which is worthy of reference.
作者
张丽姣
ZHANG Li-jiao(Liaoyang Chest Hospital,Liaoyang 111005,China)
出处
《中国现代药物应用》
2022年第19期96-98,共3页
Chinese Journal of Modern Drug Application
关键词
莫西沙星
抗结核药物
难治性结核性脑膜炎
神经生长因子
脑脊液
Moxifloxacin
Antituberculous drugs
Refractory tuberculous meningitis
Nerve growth factor
Cerebrospinal fluid
