摘要
Objective The experiment was conducted to explore the effects of silymarin on reproductive and lactation performance,serum antioxidants,and body metabolism of sows.Methods Sixty pregnant sows(85 d,Large×Landrace)with similar genetic background,body condition,and parity were randomly divided into three groups,and each group has 20 individually housed sows.The sows in the control group(CG)were fed with basal diet,and those in the experimental group A(EGA)and B(EGB)were fed with basal diet containing 250 and 500 mg/kg silymarin,respectively.The experiment lasted 46 days from day 85 of gestation to the end of lactation(weaning on day 17).The milk composition and serum biochemical para-meters were determined by a milk composition analyzer and a blood biochemical analyzer,respectively.Serum antioxidant indexes and plasma hormone levels were measured using the biochemical kits.The gas chromatograph was applied to detect the fecal short chain fatty acids.Results Compared with the CG,the total feed intake(TFI)and average daily feed intake(ADFI)were significantly increased(P<0.01),and the urea content in regular milk tended to increase(P=0.095)in the EG.The serum malondialdehyde(MDA)contents were decreased on day 90 of gestation and the day of farrowing(P<0.01),and the serum contents of total antioxidant capacity(T-AOC)tended to increase on day 17 of lactation(P=0.099)compared with the CG.Compared with the CG,the serum triglyceride(TG)concentrations in the EG tended to increase on day 90 of gestation(P=0.062),and the content of serum total protein(TP)and albumin(ALB)reduced on day 17 of lactation(P<0.01).Compared with the CG,plasm D-lactic acid content was decreased(P<0.05),and the plasma prostaglandin(PG)level tended to increase(P=0.088)in the EG on the day of farrowing and day 17 of lactation.Compared with the CG,fecal isobutyric acid concentration in the EG significantly decreased on the day of farrowing(P<0.05).Conclusion Adding 250-500 mg/kg silymarin to diets from the late gestation to the end of lactation could improve reproductive and lactation performance of sows via the regulation of nutrient metabolism and serum antioxidant.
目的本实验旨在研究水飞蓟素对母猪繁殖与泌乳性能、血清抗氧化和机体代谢的影响。方法选用遗传背景、体况和胎次相近,且受孕85 d的(长×大)二元母猪60头,随机分成3组,每组20头,单限位栏饲养。对照组饲喂基础饲粮,实验组A、B分别饲喂基础饲粮添加250、500 mg/kg水飞蓟素。实验期46 d,从妊娠第85天直至哺乳期结束(第17天断奶)。采用乳成分分析仪和血液生化分析仪分别测定乳成分和血清生化指标;利用生化试剂盒检测血清抗氧化指标和血浆激素水平;通过气象色谱技术分析粪中短链脂肪酸含量。结果与对照组相比,实验组母猪的总采食量(TFI)和平均日采食量(ADFI)极显著提高(P<0.01),常乳中的尿素含量有升高的趋势(P=0.095)。与对照组相比,实验组母猪妊娠第90天、分娩当天血清丙二醛(MDA)含量极显著下降(P<0.01),哺乳第17天血清总抗氧化力(T-AOC)含量有升高的趋势(P=0.099)。与对照组相比,实验组母猪妊娠第90天血清甘油三酯(TG)含量有升高趋势(P=0.062),哺乳第17天血清总蛋白(TP)和白蛋白(ALB)含量显著降低(P<0.01)。与对照组相比,实验组母猪分娩当天和哺乳第17天血浆D-乳酸含量显著降低(P<0.05),血浆前列腺素(PG)水平有上升趋势(P=0.088)。与对照组相比,实验组母猪分娩当天粪便中异丁酸含量显著降低(P<0.05)。结论妊娠后期至哺乳期结束,母猪饲粮中添加250−500 mg/kg水飞蓟素可通过调节母猪的营养代谢和血清抗氧化,改善母猪繁殖性能和泌乳性能。
基金
National Key Research and Development Program(2021YFD1300201 and 2021YFD1301004)
Science and Technology Innovation Program of Hunan Province(2020RC2063)
Natural Science Foundation of Hunan Province(2022JJ40532)
Open Fund of Key Laboratory of Agro-ecological Processes in Subtropical Region,Chinese Academy of Sciences(ISA2021103)
the cooperation between research institutes and enterprises(E0490205 and E0490207).
