摘要
目的探讨乙肝肝硬化患者血清乙型肝炎病毒脱氧核糖核酸(HBV-DNA)水平与肝功能、癌胚抗原(CEA)及甲胎蛋白(AFP)水平的相关性。方法回顾性分析2019年5月至2021年5月东莞市中医院收治的60例乙肝肝硬化患者的临床资料,根据HBV-DNA水平的不同分为对照组28例(1.0×103 IU/mL<HBV-DNA水平≤1.0×105 IU/mL)和观察组32例(1.0×105 IU/mL<HBV-DNA水平<1.0×108 IU/mL)。比较两组患者的谷丙转氨酶(ALT)、总胆红素(TBIL)、谷草转氨酶(AST)、CEA、AFP的水平情况,并采用Pearson相关性分析法分析血清ALT、TBIL、AST、CEA、AFP水平与血清HBV-DNA水平的相关性。结果观察组患者的血清ALT、AST、CEA、AFP水平分别为(110.12±22.04)IU/L、(96.22±18.48)IU/L、(5.90±0.40)ng/mL、(430.60±31.28)ng/mL,明显高于对照组的(91.20±20.38)IU/L、(74.51±10.60)IU/L、(3.18±0.15)ng/mL、(368.32±27.04)ng/mL,TBIL水平为(39.90±8.51)μmol/L,明显低于对照组的(66.57±10.80)μmol/L,差异均有统计学意义(P<0.05);经Pearson相关性分析结果显示,血清ALT、AST、CEA、AFP水平与HBV-DNA水平均呈正相关(r=0.721、0.518、0.424、0.705,P<0.05),TBIL水平与HBV-DNA水平呈负相关(r=-0.369,P<0.05)。结论乙肝肝硬化患者肝功能、CEA及AFP水平与血清HBV-DNA水平密切相关,对其检测有助于病情的评估和临床的治疗。
Objective To investigate the correlation between serum hepatitis B virus deoxyribonucleic acid(HBV-DNA)and liver function,carcinoembryonic antigen(CEA),alpha-fetoprotein(AFP)in patients with hepatitis B cirrhosis.Methods The clinical data of 60 patients with hepatitis B cirrhosis admitted to Dongguan Hospital of Traditional Chinese Medicine from May 2019 to May 2021 were retrospectively analyzed.According to different levels of HBV-DNA,the patients were divided into a control group(28 cases,1.0×103 IU/mL<HBV-DNA level≤1.0×105 IU/mL)and an observation group(32 cases,1.0×105 IU/mL<HBV-DNA level<1.0×108 IU/mL).The levels of alanine aminotransferase(ALT),total bilirubin(TBIL),aspartate aminotransferase(AST),CEA,and AFP were compared between the two groups.Pearson correlation analysis method was used to analyze the correlation between serum ALT,TBIL,AST,CEA,AFP level and the serum HBV-DNA level.Results The serum ALT,AST,CEA,and AFP levels of patients in the observation group were(110.12±22.04)IU/L,(96.22±18.48)IU/L,(5.90±0.40)ng/mL,(430.60±31.28)ng/mL,which were significantly higher than(91.20±20.38)IU/L,(74.51±10.60)IU/L,(3.18±0.15)ng/mL,(368.32±27.04)ng/mL in the control group,and the TBIL level was(39.90±8.51)μmol/L,significantly lower than(66.57±10.80)μmol/L in the control group,with statistically significant differences(P<0.05).Pearson correlation analysis showed that serum ALT,AST,CEA,AFP levels were positively correlated with HBV-DNA levels(r=0.721,0.518,0.424,0.705,P<0.05),and TBIL level was negatively correlated with HBV-DNA level(r=-0.369,P<0.05).Conclusion The levels of liver function,CEA,and AFP in patients with hepatitis B cirrhosis are closely related to the level of serum HBV-DNA,and the detection of these levels is helpful for the evaluation of the disease and clinical treatment.
作者
吴丹
张锡坚
陈伟
WU Dan;ZHANG Xi-jian;CHEN Wei(Department of Laboratory,Dongguan Hospital of Traditional Chinese Medicine,Dongguan 523000,Guangdong,CHINA;Department of Laboratory,Dongguan Nancheng Hospital,City,Dongguan 523071,Guangdong,CHINA)
出处
《海南医学》
CAS
2022年第21期2815-2817,共3页
Hainan Medical Journal
关键词
乙肝肝硬化
乙型肝炎病毒脱氧核糖核酸
肝功能
癌胚抗原
甲胎蛋白
Hepatitis B cirrhosis
Hepatitis B virus deoxyribonucleic acid
Liver function
Carcinoembryonic antigen
Alpha-fetoprotein
