摘要
目的探究丙戊酸钠联合拉莫三嗪治疗脑卒中继发癫痫患者的效果。方法选取我院收治的80例脑卒中继发癫痫患者作为研究对象,采用奇偶数法将其分为对照组(40例,丙戊酸钠)和研究组(40例,丙戊酸钠联合拉莫三嗪)。比较两组的治疗效果。结果治疗12个月后,研究组的癫痫发作频率低于对照组,发作持续时间短于对照组(P<0.05)。治疗12个月后,研究组的神经元特异性烯醇化酶(NSE)、基质金属蛋白酶-9(MMP-9)、S100钙结合蛋白β(S100β)水平低于对照组(P<0.05)。治疗12个月后,研究组的白细胞介素-2(IL-2)、白细胞介素-8(IL-8)及肿瘤坏死因子-α(TNF-α)水平低于对照组(P<0.05)。两组的不良反应总发生率无明显差异(P>0.05)。结论丙戊酸钠联合拉莫三嗪治疗脑卒中继发癫痫的效果显著,有利于改善患者的病症,减轻神经损伤程度与炎症反应,且不良反应少。
Objective To explore the effect of sodium valproate combined with lamotrigine in the treatment of patients with epilepsy secondary to stroke.Methods A total of 80 patients with epilepsy secondary to stroke admitted in our hospital were selected as the research objects.The patients were divided into control group(40 cases,sodium valproate)and study group(40 cases,sodium valproate combined with lamotrigine)by the odd-even method.The treatment effects of the two groups were compared.Results After 12 months of treatment,the frequency of epileptic attacks in the study group was lower than that in the control group,and the duration of attacks was shorter than that in the control group(P<0.05).After 12 months of treatment,the levels of neuron specific enolase(NSE),matrix metalloproteinase-9(MMP-9)and S100 calcium-binding proteinβ(S100β)in the study group were lower than those in the control group(P<0.05).After 12 months of treatment,the levels of interleukin-2(IL-2),interleukin-8(IL-8)and tumor necrosis factor-α(TNF-α)in the study group were lower than those in the control group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Sodium valproate combined with lamotrigine in the treatment of epilepsy secondary to stroke has a significant effect,which is beneficial to improve the symptoms of patients,reduce the degree of nerve injury and inflammation reaction,and has less adverse reactions.
作者
烟亭亭
张丹丹
YAN Tingting;ZHANG Dandan(the People's Hospital of Nanle County,Puyang 457400;the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,China)
出处
《临床医学研究与实践》
2022年第32期56-58,共3页
Clinical Research and Practice
关键词
丙戊酸钠
拉莫三嗪
脑卒中继发癫痫
sodium valproate
lamotrigine
epilepsy secondary to stroke
