摘要
目的探讨解剖性肝切除术(AR)治疗原发性肝癌(HCC)的临床疗效及相关影响因素。方法回顾性分析121例HCC患者临床资料,分析AR治疗HCC的临床疗效及相关影响因素。结果AR治疗HCC的治疗总有效率为86.378%(105/121);单因素分析显示:肿瘤大小、门静脉浸润、肝硬化、血管侵犯、肿瘤分化程度、手术切缘宽度与AR治疗HCC的临床疗效有关(P<0.05);年龄、性别、Child-Pugh分级、胆管浸润、巴塞罗那临床肝癌(BCLC)分期、包膜完整、术中输血、肿瘤数目与AR治疗HCC的临床疗效无关(P>0.05);多因素分析显示:肿瘤大小≥5 cm、门静脉浸润、肝硬化、血管侵犯、肿瘤低分化是AR治疗HCC的临床疗效的高危因素(P<0.05)。结论AR治疗HCC疗效确切,其会受肿瘤大小、门静脉浸润、肝硬化、血管侵犯、肿瘤分化程度影响。
Objective To investigate the clinical efficacy of anatomical hepatectomy(AR)in the treatment of primary liver cancer(HCC)and its related influencing factors.Methods Clinical data of 121 patients with HCC were analyzed retrospectively.Results The total effective rate of AR in treating HCC was 86.378%(105/121);Univariate analysis showed that tumor size,portal vein invasion,cirrhosis,vascular invasion,tumor differentiation,surgical margin width were related to the clinical efficacy of AR in treating HCC(P<0.05);Age,sex,Child Pugh grade,bile duct invasion,Barcelona clinical liver cancer(BCLC)stage,intact capsule,intraoperative blood transfusion,and tumor number were not related to the clinical efficacy of AR in treating HCC(P>0.05);Multivariate analysis showed that tumor size≥5 cm,portal vein invasion,cirrhosis,vascular invasion,and poor tumor differentiation were high risk factors for clinical efficacy of AR in treating HCC(P<0.05).Conclusion AR has a definite therapeutic effect on HCC,which is affected by tumor size,portal vein invasion,cirrhosis,vascular invasion and tumor differentiation.
作者
张丽娜
张慧
姚宁
ZHANG Lina;ZHANG Hui;YAO Ning(The First Affiliated Hospital of Zhengzhou University,Zhengzhou,450002)
出处
《实用癌症杂志》
2022年第11期1826-1828,共3页
The Practical Journal of Cancer
关键词
原发性肝癌
影响因素
Primary liver cancer
Influence factor
