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溶血三项网织红细胞及血清总胆红素联合检测对新生儿溶血病的诊断价值 被引量:8

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摘要 目的探究溶血三项、网织红细胞及血清总胆红素联合检测对新生儿溶血病(HDN)的早期诊断价值。方法回顾性分析2020年2月至2021年12月阜阳市人民医院收治的136例疑似HDN新生儿的临床资料。依据临床诊断结果分为HDN组102例和非HDN组34例。以临床诊断为标准,计算溶血三项诊断HDN的灵敏度特异度。比较两组患儿网织红细胞、血清总胆红素水平。绘制溶血三项、网织红细胞及血清总胆红素单检及三者联合检测诊断HDN的受试者工作特征(ROC)曲线,比较上述各项指标曲线下面积(AUC)。结果溶血三项诊断HDN的灵敏度、特异度分别为90.20%、67.65%。HDN组网织红细胞、血清总胆红素水平均高于非HDN组,差异有统计学意义(P<0.05)。ROC分析显示,网织红细胞与血清总胆红素对HDN早期诊断的最佳截断点分别为5.06%、200.43μmol/L,溶血三项、网织红细胞与血清总胆红素三者联合检测的灵敏度、特异度及AUC分别为96.08%、88.24%、0.937。结论溶血三项、网织红细胞及血清总胆红素三者联合对HDN的诊断效能较高,可作为临床HDN早期诊断的重要参考指标。
出处 《安徽医学》 2022年第11期1327-1330,共4页 Anhui Medical Journal
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