摘要
Toll样受体4是重要的固有免疫模式识别受体,通过识别损伤相关分子模式及病原相关分子模式,启动髓样分化因子88依赖途径后激活NF-κB信号通路,引发炎性介质及细胞因子的分泌,触发固有免疫应答,在膝骨关节炎滑膜炎的发生中发挥作用。研究TLR4/MyD88信号通路在膝骨关节炎滑膜炎中的作用,以期更深入的阐明膝骨关节炎滑膜炎发病机制,为膝骨关节炎滑膜炎的诊疗提供理论依据和参考。
Toll-like receptor 4 is an important innate immune pattern recognition receptor. It activates NF-κB signaling pathway by triggering myeloid differentiation factor 88-dependent pathway after identifying damage related molecular patterns and pathogen related molecular patterns, and lead to the secretion of inflammatory mediators and cytokines. It triggers innate immune response, and playing a role in the occurrence of synovitis in knee osteoarthritis. Study the role of TLR4/MyD88 signaling pathway in synovitis of knee osteoarthritis, can clarify the pathogenesis about synovitis of knee osteoarthritis and provide theoretical basis and reference for the diagnosis and treatment on synovitis of knee osteoarthritis.
作者
韩宪富
李宁
谢兴文
黄委委
李辉
HAN Xianfu;LI Ning;XIE Xingwen;HUANG Weiwei;LI Hui(Clinical College of Chinese Medicine,Gansu University of Chinese Medicine,Lanzhou 730000,China;The Department of Rehabilitation Orthopedics,Affiliated Hospital of Gansu University of Chinese Medicine,Lanzhou 730020,China;The Department of Elderly Orthopedics,Affiliated Hospital of Gansu University of Chinese Medicine,Lanzhou 730030,China)
出处
《中国骨质疏松杂志》
CAS
CSCD
北大核心
2022年第11期1690-1694,共5页
Chinese Journal of Osteoporosis
基金
国家自然科学基金地区项目(82060873)
甘肃中医药大学附属医院青年基金项目(921y-2019-08)
甘肃中医药大学中青年科研基金项目(2305016601)。
