摘要
溃疡性结肠炎是常见的肠道慢性炎症反应,溃疡性结肠炎相关癌变(ulcerative colitis related colorectal cancer,UCRCC)呈逐年上升,现已成为溃疡性结肠炎患者死亡的重要原因,其发生主要是持续的炎症反应刺激肠道黏膜,最终导致癌变的发生。NF-κB通路是诱导机体肿瘤细胞及血管内皮细胞增生、迁移、侵袭及抑制细胞凋亡的重要因素。近年来发现中医药在治疗UCRCC的作用机制可能与抗炎和抗氧化活性,抑制炎性细胞因子相关,中医药调控UCRCC的分子机制与miRNA调控NF-κB通路存在相关性。故本文就miRNA调控NF-κB通路干预UCRCC之间关系及中医药的作用进行综述。
Ulcerative Colitis is a common chronic intestinal inflammatory disease. Ulcerative colitis-associated carcinogenesis(UCRCC) has been increasing yearly, and become an important cause of death in patients with ulcerative colitis. At present, there is still lack of effective treatment methods. Its mainly occurrence related to inflammatory stimulation and mediates the continuous and chronic inflammation of the intestinal mucosa, which ultimately leads to the occurrence of dysplasia(low-grade)-carcinogenesis. The NF-κB signaling pathway is an important factor in inducing the proliferation, migration, invasion and inhibition of cell apoptosis of tumor cells and vascular endothelial cells. In recent years, it has been discovered that miRNA regulation of the NF-κB signaling pathway plays an important role in the occurrence and development of ulcerative colitis-related carcinogenesis. Traditional Chinese medicine has significant clinical efficacy in treating ulcerative colitis-related carcinogenesis. The mechanism of action of Chinese medicine may be related to anti-inflammatory and antioxidant activities. Inhibition of inflammatory cytokines is related to the molecular mechanism of Chinese medicine regulating ulcerative colitis-related carcinogenesis and miRNA regulation of NF-κB signaling pathway. This article reviews the advance in the role of miRNA regulation of NF-κB signaling pathway in affecting carcinogenesis in ulcerative colitis and Research Progress of Intervention of Traditional Chinese Medicine.
作者
刘佳丽
孙平良
肖团有
王荣
陈怒戈
李忠海
Liu Jiali;Sun Pingliang;Xiao Tuanyou;Wang Rong;Chen Nuge;Li Zhonghai(The First Affiliated Hospital of Nanjing University of Chinese Medicine,Nangjing 210023,China;The First Affiliated Hospital of Guangxi University of Chinese Medicine,Nanning 530000,China;Zhuhai Hospital of Integrated Chinese and Western Medicine,Zhuhai 519000,China)
出处
《世界科学技术-中医药现代化》
CSCD
北大核心
2022年第5期1895-1901,共7页
Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology
基金
国家自然科学基金委员会面上项目(81660795):miR-146a调控溃疡性结肠炎大鼠肠道微生态变化及安肠汤干预机制研究,负责人:孙平良。
