摘要
目的探讨妊娠期糖尿病(GDM)患者肠道菌群分布特点及其与妊娠结局的关系。方法纳入182例GDM患者(GDM组)和130例正常孕妇(健康组)。根据妊娠结局,将GDM患者分为良好组(n=61)和不良组(n=121)。收集孕妇妊娠24~28周时的粪便检测肠杆菌、肠球菌、双歧杆菌、乳杆菌、梭杆菌菌落数。比较GDM组和健康组、良好组和不良组的肠道菌群分布情况。结果与健康组相比,GDM组的肠杆菌、肠球菌菌落数增多,而双歧杆菌和乳杆菌菌落数减少(均P<0.05)。与良好组比较,不良组肠杆菌和肠球菌菌落数增多,而双歧杆菌和乳杆菌菌落数减少(均P<0.05)。结论GDM患者的肠道菌群明显紊乱,且在妊娠结局不良的患者中更为明显。肠道菌群与GDM的发生及GDM患者的妊娠结局紧密相关。
Objective To explore the characteristics of intestinal flora distribution in patients with gestational diabetes mellitus(GDM)and their relation with pregnancy outcomes.Methods A total of 182 GDM patients(the GDM group)and 130 normal pregnant women(the healthy group)were enrolled.The GDM patients were assigned to the good group(n=61)or the adverse group(n=121)according to pregnancy outcomes.The feces of pregnant women in gestational weeks of 24-28 were collected to detect the number of bacterial flora with respect to Enterobacteriaceae,Enterococcus,Bifidobacterium,Lactobacillus,Fusobacterium.The distribution of intestinal flora was compared between the GDM group and the healthy group,as well as between the good group and the adverse group.Results Compared with the healthy group,the number of bacterial flora of Enterobacteriaceae and Enterococcus in the GDM group was increased,whereas the number of bacterial flora of Bifidobacterium and Lactobacillus was decreased(all P<0.05).Compared with the good group,the number of bacterial flora of Enterobacteriaceae and Enterococcus in the adverse group was increased,while the number of bacterial flora of Bifidobacterium and Lactobacillus was decreased(all P<0.05).Conclusion The intestinal flora of GDM patients is significantly disordered,which is more obvious in patients with adverse pregnancy outcome.Intestinal flora is closely related to the occurrence of GDM and the pregnancy outcome of GDM patients.
作者
黄劲松
吕思婷
吕祝武
HUANG Jin-song;LYU Si-ting;LYU Zhu-wu(Department of Gynecology and Obstetrics,Wuxi People's Hospital Affiliated to Nanjing Medical University,Wuxi 214000,Jiangsu,China)
出处
《广西医学》
CAS
2022年第19期2222-2225,共4页
Guangxi Medical Journal
基金
江苏省无锡市妇幼健康适宜技术推广项目(FYKY201809)。
关键词
妊娠期糖尿病
肠道菌群
妊娠结局
Gestational diabetes mellitus
Intestinal flora
Pregnancy outcomes
