摘要
目的:观察甲基强的松龙冲击治疗过敏性紫癜患儿的效果。方法:选取2019年1月至2021年1月该院收治的96例过敏性紫癜患儿进行前瞻性研究,采用随机数字表法分为观察组和对照组各48例。对照组给予氢化可的松琥珀酸钠治疗,观察组给予甲基强的松龙冲击治疗,比较两组临床疗效、临床症状改善时间、治疗前后血清炎性因子[C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)和白细胞介素-6(IL-6)]水平、T细胞亚群指标水平和治疗期间不良反应发生率。结果:观察组治疗总有效率为100.00%(48/48),高于对照组的81.26%(39/48),差异有统计学意义(P<0.05);观察组恶心呕吐、皮疹、皮肤紫癜和腹痛等临床症状改善时间均短于对照组,差异有统计学意义(P<0.05);治疗后,两组CRP、TNF-α和IL-6水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);治疗后,两组CD4^(+)、CD3^(+)和CD4^(+)/CD8^(+)水平均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);两组治疗前后CD8^(+)水平比较,差异无统计学意义(P>0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:甲基强的松龙冲击治疗过敏性紫癜患儿可提高治疗总有效率,缩短临床症状改善时间,改善T细胞亚群指标水平,效果优于氢化可的松琥珀酸钠治疗。
Objective:To observe effects of Methylprednisolone pulse therapy on children with allergic purpura.Methods:A prospective study was conducted on 96 children with allergic purpura admitted to the hospital from January 2019 to January 2021.They were divided into observation group and control group by using the random number table method,48 cases in each.The control group was treated with Hydrocortisone sodium succinate,while the observation group was treated with Methylprednisolone pulse therapy.The clinical efficacy,the symptom improvement time,the serum inflammatory factor levels[C-reactive protein(CRP),tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6)]before and after the treatment,the T cell subset indexes levels,and the incidence of adverse reactions during the treatment were compared between the two groups.Results:The total effective rate of treatment in the observation group was 100.00%(48/48),which was higher than 81.26%(39/48)in the control group,and the difference was statistically significant(P<0.05).The improvement times of clinical symptoms such as vomiting,rash,skin purpura and abdominal pain in the observation group were shorter than that in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of CRP,TNF-αand IL-6 in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of CD4^(+),CD3^(+)and CD4^(+)/CD8^(+)in the two groups were higher than those before the treatment,those of the observation group were higher than those of the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the CD8^(+)level between the two groups before and after treatment(P>0.05).Further,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Methylprednisolone pulse therapy in the children with allergic purpura can improve the total effective rate,shorten the improvement time of clinical symptoms,and improve the T cell subsets indexes levels.Moreover,it is superior to Hydrocortisone sodium succinate treatment.
作者
许耀
岳喜波
XU Yao;YUE Xibo(Children’s Hospital Affiliated to Zhengzhou University,Henan Children’s Hospital,Zhengzhou Children’s Hospital,Zhengzhou450000 Henan,China)
出处
《中国民康医学》
2022年第20期70-72,76,共4页
Medical Journal of Chinese People’s Health
