摘要
目前全球现有5.37亿成人糖尿病患者,预计到2045年将达到7.83亿,其中超过90%是2型糖尿病(type 2 diabetes mellitus,T2DM),2021年造成全球600多万人死亡[1],而绝大多数死于糖尿病并发症。作为糖尿病并发症中的一种,糖尿病心肌病(diabetic cardiomyopathy,DCM)是在不合并冠状动脉疾病、高血压、先天性心脏病和瓣膜性心脏病等情况下,发生的心肌结构和功能异常的心肌病。DCM的特征是早期左室肥厚和纤维化,进而舒张功能减退,晚期出现广泛的心肌纤维化、收缩功能障碍和左室扩张,导致死亡率增加。
Diabetic cardiomyopathy is one of the irreversible chronic serious cardiovascular complications of diabetic patients.Recent studies have shown that cardiomyocyte lipotoxicity caused by diabetic lipid metabolism disorder may be the basis and key factor for the occurrence and development of diabetic cardiomyopathy.Lipotoxicity leads to diabetic cardiomyopathy by inducing myocardial inflammation,oxidative stress,insulin resistance,myocardial fibrosis,and microvascular dysfunction,resulting in apoptosis,myocardial fibrosis,and diastolic dysfunction.Diabetic cardiomyopathy can eventually progress to heart failure which results in increased mortality of patients.At present,the specific mechanism of cardiomyocyte lipotoxicity leading to the occurrence and development of diabetic cardiomyopathy is still unclear.Therefore,this article reviews the role and possible mechanism of lipotoxicity in the pathogenesis of diabetic cardiomyopathy in order to provide a reference for basic research and clinical diagnosis and treatment.
作者
宋小刚
陈子仪
马霞
张妍妍
吴冰
陈永清
SONG Xiao-gang;CHEN Zi-yi;MA Xia;ZHANG Yan-yan;WU bing;CHEN Yong-qing(The Second Clinical Medical Collage of Lanzhou University,Lanzhou 730030,China;Department of Cardiology,the 940th Hospital of Joint Logistics Support Force of Chinese People's Liberation Army,Lanzhou 730050,China;Key Laboratory of Stem Cells and Gene Drugs,Gansu Province,Lanzhou 730050,China;Department of Geriatrics,the 940th Hospital of Joint Logistics Support Force of Chinese People's Liberation Army,Lanzhou 730050,China;Department of Cardiolo-gy,Gansu Provincial Central Hospital,Lanzhou 730070,China)
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
2022年第11期2106-2112,共7页
Chinese Journal of Pathophysiology
基金
甘肃省自然科学基金资助项目(No.18JR3RA402)
西北民族大学课题(No.31920200012)
甘肃省卫生健康行业科研计划项目(No.GSWSKY2020-13)
联勤保障部队第九四〇医院科研计划(No.2021yxky038)。
关键词
脂肪酸
脂毒性
糖尿病心肌病
Fatty acid
Lipotoxicity
Diabetic cardiomyopathy
