摘要
NK细胞在先天性免疫和适应性免疫中发挥关键作用,探究NK细胞的新亚型和异质性有助于了解NK细胞的不同功能。单细胞测序技术能够无偏倚地对单个细胞进行分析,目前单细胞RNA测序(single-cell RNA sequencing, scRNA-seq)已广泛应用于多个领域,尤其是在免疫学方面。该文总结了利用scRNA-seq技术进行NK细胞研究的策略,讨论了通过scRNA-seq技术揭示的NK细胞在不同组织中的异质性和功能。
NK cells play critical roles in innate and adaptive immunity.Exploring novel subtypes and heterogeneity of NK cells will promote the understanding of the different functions of NK cells.Single-cell RNA sequencing(scRNA-seq),which provides unbiased analysis of individual cells,has been widely used in numerous fields,especially immunology.In this review,we summarized the strategies to study NK cells using scRNA-seq and discussed NK cell heterogeneity and function revealed by scRNA-seq in different tissues.
作者
包梦颖
曾燕玉
代艳
莫曾南
BAO Meng-ying;ZENG Yan-yu;DAI Yan;MO Zeng-nan(Center for Genomic and Personalized Medicine,Guangxi Medical University,Nanning 530021,China;Guangxi Key Laboratory for Genomic and Personalized Medicine,Nanning 530021,China;Guangxi Collaborative Innovation Center for Genomic and Personalized Medicine,Nanning 530021,China;Laboratory Department,Guizhou Orthopedic Hospital,Guiyang 550002,China;Emergency Department,The Second Affiliated Hospital of Guangxi Medical University,Nanning 530021,China)
出处
《现代免疫学》
CAS
北大核心
2022年第5期447-451,456,共6页
Current Immunology
基金
国家自然科学基金(81770759)
广西创新驱动重大项目(AA 18118016)
国家重点研究开发项目(2017YFC0908000)。
