摘要
目的探讨肠道病毒分型和T淋巴细胞亚群与手足口病(HFMD)病情程度的关系。方法分析HFMD患儿92例(HFMD组)及健康儿童40例(对照组)的临床资料,HFMD组按照病情程度分为重症组和轻症组。探讨HFMD患儿肠道病毒分型和T淋巴细胞亚群与HFMD病情程度的关系。结果HFMD患儿肠道病毒感染以单一感染为主,其中柯萨奇病毒A16(CA16)和CA6构成比较高;重症组与轻症组病毒分型情况比较差异无显著性(P>0.05)。CD3^(+)、CD4^(+)、CD8^(+)及CD4^(+)/CD8^(+)水平HFMD组低于对照组,重症组低于轻症组(P<0.05)。结论HFMD患儿T淋巴细胞亚群检测分析有助于其临床诊断和病情判断。
Aim To explore the relationship between enterovirus typing and T lymphocyte subsets and the severity of hand-foot-mouth disease(HFMD).Methods The clinical data of 92 children with HFMD(HFMD group)and 40 healthy children(control group)were analyzed.The HFMD group was divided into severe group and mild group according to the degree of illness.Explore the relationship between enterovirus typing and T lymphocyte subsets and the severity of HFMD in children.Results Enterovirus infection in children with HFMD is mainly single infection,and Coxsackievirus A16(CA16)and CA6 had higher composition.There was no significant difference in virus typing between severe group and mild group(P>0.05).The levels of CD3^(+),CD4^(+),CD8^(+)and CD4^(+)/CD8^(+)in HFMD group were lower than control group,and those in severe group were lower than mild group(P<0.05).Conclusion The detection and analysis of T lymphocyte subsets in children with HFMD is helpful to the clinical diagnosis and judgment of the disease.
作者
李欣
李小明
黎小年
林杰
吉祥灵
LI Xin;LI Xiaoming;LI Xiaonian;LIN Jie;JI Xiangling(Department of General Pediatrics,Hainan Women and Children Medical Center,Haikou 570206,Hainan,China;Department of Pediatrics,Qiongshan Maternal and Child Health Hospital,Haikou 571100,Hainan,China)
出处
《中南医学科学杂志》
CAS
2022年第6期876-878,共3页
Medical Science Journal of Central South China
基金
海南省卫生健康行业科研项目(20A200330)
海南省临床医学中心建设项目资助。
关键词
手足口病
T淋巴细胞亚群
肠道病毒
柯萨奇病毒
病情程度
hand-foot-mouth disease
T lymphocyte subsets
enterovirus
Coxsackievirus
disease severity
