摘要
目的建立骨质增生胶囊质量标准。方法利用薄层色谱法对处方中的三七、川芎和当归进行了定性鉴别;采用高效液相色谱法测定处方中人参皂苷Rb_(1)的含量。结果TLC可鉴别出与三七、当归和川芎相对应的斑点;人参皂苷Rb_(1)在0.0824〜2.06 mg・ml^(-1)浓度范围内呈良好的线性关系,相关系数为1.0000。样品中人参皂苷Rb1的平均加样回收率为98.36%,RSD为1.35%(n=6)。结论本文中建立的骨质增生胶囊质量标准全面系统、准确可靠,可为其生产和质量控制提供科学依据。
Objective To establish a quality standard for Guzhizengsheng capsules.Methods Sanchi,Chinese Angelica and Szechwan Lovage Rhizome in Guzhizengsheng capsules were identified by TLC.Ginsenoside Rb_(1) in these capsules was determined by HPLC.Results The related spots of Sanchi,Chinese Angelica and Szechwan Lovage Rhizome were identified by TLC.Ginsenoside Rbi showed a good linear relationship in the range of 0.0824 to 2.06 mg•ml^(-1),r=1.0000.The average recovery of ginsenoside Rb_(1) was 98.36%(RSD=1.35%,n=6).Conclusion This quality standard is simple,feasible,repeatable and reliable enough to control the production and quality of Guzhizengsheng capsules.
作者
张贵英
胡丹
曹红
ZHANG Gui-ying;HU Dan;CAO Hong(Administration for Drug and Instrument Supervision and Inspection of PLAJLSF,Beijing 100166,China)
出处
《解放军药学学报》
CAS
2022年第2期125-128,共4页
Pharmaceutical Journal of Chinese People's Liberation Army
基金
全军医疗机构制剂标准提高科研专项课题,No.13ZJZ16。
