摘要
目的:探讨小儿宝泰康颗粒联合磷酸奥司他韦治疗风热犯卫证甲型流行性感冒的临床疗效及作用机制。方法:选取2021年10月至2022年7月武汉市中医医院儿科门诊收治的甲型流行性感冒风热犯卫证患儿70例作为研究对象,采用随机数字表法分为观察组和对照组,每组35例。对照组给予基础治疗,以退热、补液为主,口服磷酸奥司他韦颗粒;观察组在对照组基础上加口服小儿宝泰康颗粒治疗,疗程5 d。观察记录患儿完全热退时间、卡他症状消退时间、咳嗽消退时间,并对其进行评分判断疗效,同时在入组第1天、第5天采血化验炎症介质超敏C反应蛋白(hs-CRP)、降钙素原(PCT)及白细胞介素-6(IL-6)含量,观察2组不良反应的发生情况,采用SPSS 26.0统计软件进行数据分析。结果:观察组总有效率97.14%,对照组总有效率85.71%,观察组优于对照组(P<0.01);与对照组比较,观察组完全热退时间、卡他症状消退时间、咳嗽消退时间短,差异有统计学意义(均P<0.05);治疗后,2组hs-CRP、PCT及IL-6水平与治疗前相较均有降低,且观察组hs-CRP、PCT及IL-6均明显低于对照组(均P<0.05)。结论:小儿宝泰康颗粒联合磷酸奥司他韦可以明显加快风热犯卫证甲流患儿完全退热时间,缩短病程,改善发热、咳嗽、腹胀等症状,降低炎症介质水平,对于治疗以风热犯卫证甲型流行性感冒具有较好的临床疗效,无明显不良反应,其作用机制可能与调节内致热原,抑制炎症介质分泌有关。
Objective:To investigate the clinical effect and mechanism of Xiaoer Baotaikang Granules combined with oseltamivir phosphate in the treatment of influenza A with wind-heat invading defensive qi.Methods:A total of 70 children with influenza A positive and syndrome of wind-heat invading defensive qi treated in the Department of Pediatrics of Wuhan Hospital of Traditional Chinese Medicine from October 2021 to July 2022 were selected and divided into an observation group and a control group by random number table, with 35 cases in each group.The control group was given basic treatment, mainly antipyretics and rehydration, combined with oral administration of oseltamivir phosphate granules.The observation group was treated with Xiaoer Baotaikang Granules on the basis of the control group.After 5 days of treatment, the time of fever, catarrhal symptoms and cough disappearance were observed and recorded, and the curative effect was evaluated.Additionally, the levels of inflammatory factors high-sensitivity C-reactive protein(hs-CRP),procalcitonin(PCT),and interleukin-6(IL-6) were tested on the 1 st and 5 th day after admission, and the occurrence of adverse reactions in the two groups was observed.Finally, SPSS 26.0 was used for data analysis to compare the difference between the two groups.Results:The total effective rate of the observation group was 97.14%,higher than 85.71% of the control group(P<0.01).The time of fever, catarrhal symptoms and cough disappearance in the observation group were shorter than those in the control group(all P<0.05).After treatment, the levels of hs-CRP,PCT and IL-6 in the two groups were decreased compared with the conditions before treatment, and the levels in the observation group were lower than those in the control group(all P<0.05).Conclusion:Xiaoer Baotaikang Granules combined with oseltamivir phosphate could significantly accelerate the time of fever disappearance, shorten the course of disease, improve fever, cough, abdominal distension and other symptoms, and reduce the levels of inflammatory factors in children with influenza A and wind-heat invading defensive qi, showing good clinical efficacy and without obvious adverse reactions.Its mechanism might be related to the regulation of internal heat source and the inhibition of inflammatory factor secretion.
作者
刘盈
蔡建新
徐和祥
柳祥坤
LIU Ying;CAI Jianxin;XU Hexiang;LIU Xiangkun(Department of Pediatrics,Wuhan Hospital of Traditional Chinese Medicine,Wuhan 430014,China)
出处
《世界中医药》
CAS
2022年第20期2916-2919,共4页
World Chinese Medicine
基金
湖北省卫生健康委员会中医药科研项目(ZY2021Z008)。
