摘要
目的分析体检人群血清电解质浓度与心血管事件风险的关联性。方法采用横断面研究方法,选取2018年1月1日—2022年2月28日在华中科技大学同济医学院附属同济医院体检中心进行健康体检且测定过血清高敏心肌肌钙蛋白I(hs-cTnI)和血清电解质(氯、磷、钙、钠、钾、镁离子)的8445例成年人为研究对象,根据hs-cTnI浓度将心血管事件风险划分为低、中、高3个等级。采用方差分析比较不同心血管事件风险等级体检者血清电解质浓度差异,采用有序多分类logistic回归分析血清电解质浓度与心血管事件风险的关联。结果心血管事件低风险组钾、镁离子浓度均高于中、高风险组[钾离子(4.28±0.29)比(4.24±0.34)、(4.23±0.36)mmol/L,镁离子(0.88±0.06)比(0.87±0.07)、(0.87±0.07)mmol/L](均P<0.05),钠离子浓度低于中、高风险组[(140.54±1.75)比(140.88±1.73)、(140.81±2.20)mmol/L](P<0.001);高风险组磷离子浓度低于中、低风险组[(1.04±0.17)比(1.08±0.16)、(1.05±0.15)mmol/L](P=0.001);各组氯、钙离子浓度差异均无统计学意义(均P>0.05)。相比于离子浓度正常者,低钾血症(OR=6.96,95%CI:3.67~13.10)、低镁血症(OR=5.00,95%CI:1.01~24.50)者心血管事件风险等级均更高(均P<0.05);在正常范围内,钠离子浓度与心血管事件风险呈正相关(OR=1.08,95%CI:1.03~1.14;P<0.001)。结论体检人群血清钠、钾、镁离子浓度与心血管事件风险有关,维持体内钾、镁离子的相对稳态以及钠离子在正常范围内的较低水平,可能有助于预防心血管事件发生。
Objective To analyse the relationship between serum electrolyte concentrations and risk of cardiovascular events in physical examination population.Methods A cross-sectional study design was applied to survey 8445 adults whose serum high-sensitivity cardiac troponⅠ(hs-cTnⅠ)and serum electrolytes(chloride,phosphorus,calcium,sodium,potassium and magnesium)concentrations were measured at the health examination center of Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology from January 1,2018 to February 28,2022.The risk of cardiovascular events was classified into three levels according to the serum hypersensitive cardiac troponinⅠ(hs-cTnⅠ)concentration:low,middle or high risk group.One-way analysis of variance was applied to compare the differences in serum electrolyte concentrations of participants with different risk levels of cardiovascular events.Ordered multi-category logistic regression was performed to analyze the correlation between serum electrolyte levels and the risk of cardiovascular events.Results The concentration of potassium and magnesium ion in the subjects with low risk of cardiovascular events were both higher than those in the middle and high risk group[potassium ion(4.28±0.29)vs(4.24±0.34),(4.23±0.36)mmol/L,magnesium ion(0.88±0.06)vs(0.87±0.07),(0.87±0.07)mmol/L](both P<0.05),while the concentration of sodium ion was lower[(140.54±1.75)vs(140.88±1.73),(140.81±2.20)mmol/L](P<0.001);the concentration of phosphorus ion in the high-risk group was lower than those in the middle and low risk groups[(1.04±0.17)vs(1.08±0.16),(1.05±0.15)mmol/L](P=0.001);no significant difference was found in the concentrations of chloride and calcium ion among the three groups(both P>0.05).Compared to subjects with normal concentrations of electrolyte,the risk level of cardiovascular events in subjects with hypokalemia(OR=6.96,95%CI:3.67-13.10)and hypomagnesemia(OR=5.00,95%CI:1.01-24.50)was higher(both P<0.05).Within the normal range,sodium concentration was positively correlated with the risk of cardiovascular events(OR=1.08,95%CI:1.03-1.14;P<0.001).Conclusions The serum sodium,potassium and magnesium concentrations in health examination subjects are correlated with the risk of cardiovascular events.Maintaining the balanced concentration of serum potassium and magnesium,as well as low sodium levels within normal limits may help prevent cardiovascular events.
作者
黄玉钗
万政策
胡柳
黄元成
吕永曼
雷小妹
Huang Yuchai;Wan Zhengce;Hu Liu;Huang Yuancheng;Yongman Lü;Lei Xiaomei(Physical Examination Center,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China)
出处
《中华健康管理学杂志》
CAS
CSCD
2022年第10期696-700,共5页
Chinese Journal of Health Management
基金
湖北省2020年低碳试点专项资金(鄂环函(2021)15号)。
关键词
血清
电解质
心血管事件
危险
体格检查
高敏心肌肌钙蛋白I
Serum
Electrolytes
Cardiovascular events
Risk
Health examination
High-sensitivity cardiac tropon I
