摘要
肠肺轴是指胃肠道和呼吸道可能在多个层面上存在内在联系与相互作用。研究发现肠道菌群可能通过肠肺轴与早产儿支气管肺发育不良(bronchopulmonary dysplasia,BPD)的发生和进展有着密切联系。研究二者之间相互作用的机制有助于从微生态学角度进一步探索BPD新的治疗靶点与方向。该文综述了肠道菌群与BPD的相关性,并从胰岛素样生长因子-1、代谢组学、免疫调控、直接转移及营养等方面分别阐述了肠肺轴对早产儿BPD的影响机制研究进展,为预防和治疗BPD提供了新的研究思路。
The gut-lung axis refers to the internal relationship and interaction between the gastrointestinal tract and the respiratory tract at multiple levels.Studies have found that gut microbiota may be closely related to the occurrence and progression of bronchopulmonary dysplasia(BPD)in preterm infants through the gut-lung axis.Studying the mechanism of the interaction between them will help us to extend new therapeutic targets and directions from the perspective of microecology for BPD infants.This article reviews the correlation between gut microbiota and BPD,and the research progress of the mechanism of the gut-lung axis in premature BPD from the aspects of insulin-like growth factor 1,metabolomics,immune regulation,direct transfer,and nutrition.It provides new research ideas for the prevention and treatment of BPD.
作者
王丹虹(综述)
逯军(审校)
Wang Danhong;Lu Jun(Department of Children′s Medicine,Affiliated Haikou Hospital of Xiangya Medical College,Central South University,Haikou 570208,China)
出处
《国际儿科学杂志》
2022年第9期620-624,共5页
International Journal of Pediatrics
关键词
早产儿
肠肺轴
支气管肺发育不良
肠道菌群
Premature
Gut-lung axis
Bronchopulmonary dysplasia(BPD)
Gut microbiota
