摘要
克拉拉细胞分泌蛋白16(Clara cell secretory protein 16,CC16)是呼吸道上皮Clara细胞最主要的分泌蛋白之一,主要存在于肺上皮细胞衬液中,当支气管肺泡-毛细血管膜屏障受损时CC16会大量进入血液,最终随着尿液排出体外。近年来,越来越多研究发现CC16不仅具有抗炎、调节免疫、抗氧化和抗纤维化等作用,其浓度水平的变化还是反应气道上皮完整性的一个敏感指标,能预测多种儿童肺部疾病的发生发展。该文主要对CC16的生物学特性及作用进行总结,并就其在儿童肺部疾病诊治中的研究进展作一综述。
Clara cell secretory protein 16(CC16)is one of the most important secreted proteins of Clara cells in respiratory epithelium,which mainly exists in the lining fluid of lung epithelial cells.When the bronchoalveolus-capillary membrane barrier is damaged,a large amount of CC16 will enter the blood.It′s eventually excreted in the urine.In recent years,more and more studies have found that CC16 not only has anti-inflammatory,immune-modulating,anti-oxidation and anti-fibrosis effects,but also is a sensitive indicator of the integrity of the airway epithelium,which can predict the occurrence and development of many children′s pulmonary diseases.This article mainly summarizes the biological characteristics and functions of CC16,and summarizes the research progress of CC16 in the diagnosis and treatment of pediatric pulmonary diseases.
作者
黎历(综述)
晋兴楠
王旭
邹映雪(审校)
Li Li;Jin Xingnan;Wang Xu;Zou Yingxue(Respiratory Department of Machang District,Tianjin Children′s Hospital(Tianjin University Children′s Hospital),Tianjin 300074,China)
出处
《国际儿科学杂志》
2022年第9期625-628,共4页
International Journal of Pediatrics
基金
天津市自然基金重大项目(20JCZDJC00630)。
