摘要
目的探讨云南地区非缺失型α珠蛋白生成障碍性贫血基因型在珠蛋白生成障碍性贫血(简称“地贫”)防控中的应用。方法采用PCR+膜杂交法对受检标本进行α^(WS)α、α^(CS)α、α^(QS) 3种常见的非缺失型α地贫基因突变检测。结果18587例受检者中共检出非缺失型364例,阳性率为1.96%。结论该研究初步阐明了云南地区非缺失型α地贫基因的分布特征,为该地区制订有效、可行的地贫防控策略提供了参考依据。
Objective To explore the application of non-deletion α-thalassemia genotypes in the prevention and control of thalassemia in Yunnan.Methods PCR+membrane hybridization method was used to detect α^(WS)α,α^(CS)α,α^(QS) three common non-deletionα-thalassemia gene mutations.Results A total of 364 cases of non-deletion type were detected in 18587 subjects,and the positive rate was 1.96%.Conclusion This study preliminarily clarified the distribution characteristics of non-deletionα-thalassemia genes in Yunnan,and provided a reference for formulating effective and feasible thalassaemia prevention and control strategies in this region.
作者
王丽媛
彭晓建
田金蓉
倪秀静
曾敬富
WANG Liyuan;PENG Xiaojian;TIAN Jinrong;NI Xiujing;ZENG Jingfu(Kunming Jinyu Medical Laboratory Co.,Ltd.,Kunming,Yunnan 650500,China)
出处
《检验医学与临床》
CAS
2022年第S02期10-13,共4页
Laboratory Medicine and Clinic
基金
云南省昆明市卫生健康委员会审批项目(2020-11-01-121)。
