摘要
目的:探讨术后预防性肝动脉化疗栓塞术(TACE)联合抗肿瘤药物对原发性肝癌合并微血管侵犯患者术后生存率的影响。方法:选择南昌市第九医院肝胆外科2016年3月-2020年3月收治的100例存在微血管浸润并行根治性手术治疗的原发性肝癌患者为研究对象。单纯进行手术治疗的28例患者为手术组;术后预防性应用TACE的35例患者为TACE组;术后预防性行TACE联合抗肿瘤药物的37例患者作为联合组。比较三组术后肝癌复发情况,并发症发生情况,1、2年生存率。结果:在随访期间,手术组中出现11例复发,TACE组出现7例复发,联合组出现5例复发。三组复发率比较,差异有统计学意义(P<0.05);三组术后发热、恶心、呕吐、上腹痛、肝功能异常等并发症发生率进行对比,差异无统计学意义(P>0.05);通过对三组生存率进行比较,联合组1、2年生存率均明显高于另外两组,差异均有统计学意义(P<0.05)。结论:原发性肝癌合并微血管侵犯患者术后应用预防性TACE联合抗肿瘤药物,不会额外增加患者发生并发症的潜在可能性,并以此为基础延长了患者的生存期。
Objective:To investigate the effect of postoperative prophylactic TACE combined with antitumor drugs on postoperative survival rate of patients with primary liver cancer complicated with microvascular invasion.Method:A total of 100 patients with primary carcinoma of the liver complicated with microvascular invasion treated by radical surgery in the Department of Hepatobiliary Surgery,the Ninth Hospital of Nanchang from March 2016 to March 2020 were selected as the research objects.28 patients who only underwent surgery were taken as the operation group;35 patients who received postoperative prophylactic TACE were included in the TACE group,postoperative 37 patients who received preventive TACE combined with antitumor drugs were taken as the combined group.The recurrence of liver cancer,the incidence of complications and the survival rates after 1 and 2 years were compared among the three groups.Result:During the follow-up period,recurrence occurred in 11 cases in the operation group,7 cases in the TACE group and 5 cases in the combined group.There was significant difference in the recurrence rate among the three groups (P<0.05).There was no significant difference in incidence postoperative complications such as fever,nausea,vomiting,upper abdominal pain and abnormal liver function among the three groups (P>0.05).By comparing the survival rates of the three groups,the survival rates of the combined group at 1 and 2 years were significantly higher than those of the other two groups,the differences were statistically significant (P<0.05).Conclusion:Postoperative application of prophylactic TACE combined with antineoplastic drugs in patients with primary liver cancer complicated with microvascular invasion will not increase the potential possibility of complications,and prolong the survival time of the patients.
作者
曹涌
高华
毛卫
余海滨
叶德强
CAO Yong;GAO Hua;MAO Wei;YU Haibin;YE Deqiang(The Ninth Hospital of Nanchang,Nanchang 330000,China;不详)
出处
《中国医学创新》
CAS
2022年第31期50-54,共5页
Medical Innovation of China
