摘要
目的:借助中医传承辅助平台系统软件,分析抑郁症中药复方专利的用药规律,为临床遣方用药及新药开发提供依据。方法:登录国家知识产权局中国专利公布公告网站(http://epub.sipo.gov.cn/),检索2015—2020年治疗抑郁症的复方中药专利,借助中医传承辅助平台(V2.5),采用频数统计、关联原则、复杂系统熵聚类等数据挖掘方法对核心药物及其性味、归经、组方规律及新处方进行分析研究。结果:共纳入治疗抑郁症的中药复方专利126项,涉及药物176味;常用药物为柴胡、郁金、酸枣仁、白芍、合欢皮等;常用药对为白芍-柴胡,郁金-白芍,当归-柴胡,郁金-柴胡;药味以甘、苦、辛为主,药性以温药居多,归经多属肝、心、脾经,并得到药物之间的关联规则,置信度较高的关联规则有“当归,白芍->柴胡”“甘草,白芍->柴胡”等;共有20对核心组合;新处方10首。结论:借助中医传承辅助系统分析复方中药专利治疗抑郁症的用药规律,有助于为临床治疗提供新思路,并为选方用药提供参考依据。
Objective:To analyze the medication rules of Chinese patent medicine compounds in the treatment of depression by virtue of the Traditional Chinese Medicine Inheritance Support System(TCMISS)to provide a basis for clinical drug formulation and new drug development.Methods:National patents on Chinese medicine compounds against depression in 2015—2020 were retrieved from the website of the China National Intellectual Property Administration(http://epub.sipo.gov.cn/).By TCMISS,the core drugs,as well as their nature,flavor,meridian tropism,formulation rules,and new prescriptions were analyzed by data mining methods such as frequency statistics,association rules,and complex system entropy clustering.Results:A total of 126 Chinese patent medicine compounds in the treatment of depression were included,involving 176 single drugs.The commonly used drugs included Bupleuri Radix,Curcumae Radix,Ziziphi Spinosae Semen,Paeoniae Radix Alba,and Albiziae Cortex.The commonly used drug pairs were Paeoniae Radix Alba-Bupleuri Radix,Curcumae Radix-Paeoniae Radix Alba,Angelicae Sinensis Radix-Paeoniae Radix Alba,and Curcumae Radix-Paeoniae Radix Alba.The drugs were mainly sweet,bitter,and pungent in flavor and warm in nature,and acted on liver,heart,and spleen meridians.The association rules between drugs indicated“Angelicae Sinensis Radix,Paeoniae Radix Alba->Bupleuri Radix”“Glycyrrhizae Radix et Rhizoma,Paeoniae Radix Alba->Bupleuri Radix”,etc.with high confidence.There were 20 pairs of core combinations and 10 new prescriptions.Conclusion:By TCMISS,this paper analyzed medication rules of Chinese patent medicine compounds in the treatment of depression to provide new ideas for clinical treatment and references for drug selection and formulation.
作者
熊霞军
胡志希
钟森杰
杨梦
叶嘉豪
XIONG Xiajun;HU Zhixi;ZHONG Senjie;YANG Meng;YE Jiahao(Hunan University of Chinese Medicine,Changsha 410208,China)
出处
《世界中医药》
CAS
2022年第22期3242-3246,共5页
World Chinese Medicine
基金
国家自然科学基金项目(81774208)--基于TGF-β/Smad通路探讨高血压心衰证候本质及心肾纤维化机制
湖南省自然科学基金项目(2019JJ50447)--基于代谢调控网络探讨高血压心力衰竭本质。
关键词
抑郁症
用药规律
中药复方专利
传承辅助系统
关联规则
Depression
Medication regulation
Patents of Chinese medicine compounds
Inheritance support system
Association rules
