摘要
目的分析左乙拉西坦联合奥卡西平治疗对儿童局灶性癫痫神经损伤及认知功能的治疗效果。方法选取2019年6月至2021年6月该院收治的100例局灶性癫痫患儿为研究对象,将其分为对照组及观察组,每组50例。对照组采用奥卡西平治疗,观察组采用左乙拉西坦联合奥卡西平治疗。比较两组临床疗效,脑电图α、β、δ、θ频段功率,神经损伤指标[血清中枢神经特异性蛋白(S-100β)、髓鞘碱性蛋白(MBP)、胶质纤维酸性蛋白(GFAP)、高迁移率族蛋白B1(HMGB1)]水平,以及认知功能言语智商(VIQ)、操作智商(PIQ)、总智商(FIQ)评分。结果治疗后,观察组总有效率高于对照组(P<0.05)。治疗前,两组脑电图α、β、δ、θ频段功率,神经损伤指标S-100β、MBP、GFAP、HMGB1水平,以及认知功能VIQ、PIQ、FIQ评分比较,差异均无统计学意义(P>0.05)。治疗后,两组脑电图各频段功率、认知功能各项评分较治疗前均升高(P<0.05),且观察组均高于对照组(P<0.05);神经损伤指标水平较治疗前均降低(P<0.05),且观察组低于对照组(P<0.05)。结论左乙拉西坦联合奥卡西平治疗儿童局灶性癫痫效果更佳,能提高患儿的脑电图各频段功率,减轻神经损伤,改善认知功能,值得临床应用。
Objective To analyze the therapeutic effect of levetiracetam combined with oxcarbazepine on neurological injury and cognitive function of focal epilepsy in children.Methods A total of 100 children with focal epilepsy treated admitted to this hospital from June 2019 to June 2021 were selected as the research objects.They were randomly divided into the control group and the observation group according to the odd-even number method of admission number,with 50 cases in each group.The control group was treated with oxcarbazepine,and the observation group was treated with levetiracetam combined oxcarbazepine.The clinical efficacy,electroencephalogramα,β,δandθfrequency band power,neurological injury indicators[serum S-100β,myelin basic protein(MBP),glial fibrillary acidic protein(GFAP),high mobility group B1(HMGB1)]levels and cognitive function(VIQ,PIQ and FIQ)scores were compared between the two groups.Results After treatment,the total effective rate of the observation group was higher than that of the control group(P<0.05).Before treatment,there was no statistical significance in the difference of electroencephalogramα,β,δandθfrequency band power,neurological injury indicators levels of S-100β,MBP,GFAP,HMGB1,as well as cognitive function(VIQ,PIQ and FIQ)scores(P>0.05).After treatment,the power of each frequency band of electroencephalogram and the scores of cognitive function of the two groups were higher than those before treatment(P<0.05),and those in the observation group were higher than those in the control group(P<0.05);the levels of neurological injury indicators were lower than those before treatment(P<0.05),and those in the observation group were lower than those in the control group(P<0.05).Conclusion Levetiracetam combined with oxcarbazepine is more effective in the treatment of focal epilepsy in children.It could improve the power of each frequency band of electroencephalogram,reduce nerve damage and improve cognitive function,which is worthy of clinical application.
作者
秦婉玉
张琦
QIN Wanyu;ZHANG Qi(Department of Pediatrics,People′s Hospital of Tongchuan,Tongchuan,Shaanxi 727000,China)
出处
《检验医学与临床》
CAS
2022年第23期3246-3249,共4页
Laboratory Medicine and Clinic
关键词
儿童局灶性癫痫
左乙拉西坦
奥卡西平
脑电图
神经损伤
认知功能
focal epilepsy in children
levetiracetam
oxcarbazepine
electroencephalogram
neurological injury
cognitive function
