摘要
目的观察温肾健脾定脊汤辅助西医治疗对强直性脊柱炎患者炎症因子、脊柱功能的影响。方法回顾性分析选取2021年1月至2022年1月黄河三门峡医院收治的120例强直性脊柱炎患者为研究对象,经抽签法将其分为两组,将60例仅予以常规西医治疗的患者列为西药组,将60例采用温肾健脾定脊汤辅助西医治疗的患者列为中西医组,治疗结束后统一进行为期6个月短期随访,比较两组治疗后的证候积分、炎症因子、疼痛程度变化情况及随访期间的脊柱功能恢复情况。结果治疗后,中西医组的腰脊冷痛、屈伸不利等中医主证以及腿膝酸软、畏寒肢冷等中医次证积分低于西药组,治疗后C-反应蛋白(CRP)、降钙素原(PCT)、白细胞介素-6(IL-6)、红细胞沉降率(ESR)等炎症因子水平低于西医组,治疗后3、7、14 d的视觉模拟疼痛(VAS)评分低于西医组,差异具有统计学意义(P<0.05);随访期间,中西医组的Bath强直性脊柱炎病情活动指数(BASDAI)、Bath强直性脊柱炎功能指数(BASFI)低于对照组、Bath强直性脊柱炎衡量指数(BASMI)高于对照组,差异具有统计学意义(P<0.05)。结论在予以强直性脊柱炎患者常规西医治疗基础上,联合应用温肾健脾定脊汤辅助治疗可进一步改善患者中医证候、体征,对缓解患者疼痛、控制炎症因子水平、改善脊柱功能均有积极意义。
Objective To observe the effect of Wenshen Jianpi Dingji decoction assisted Western medicine on inflammatory factors and spinal function in patients with ankylosing spondylitis.Methods A retrospective analysis was conducted on 120 patients with ankylosing spondylitis admitted to Sanmenxia Hospital of Yellow River from January 2021 to January 2022.They were divided into two groups by lottery.60 patients receiving conventional Western medicine treatment were classified as Western medicine group,and 60 patients receiving Wenshen Jianpi Dingji decoction assisted Western medicine treatment were classified as traditional Chinese and Western medicine group.Short-term follow-up was conducted for 6 months after treatment,and the changes of symptom scores,inflammatory factors,and pain degree after treatment,and the recovery of spinal function during follow-up were compared between the two groups.Results After treatment,the scores of TCM main syndroms such as lumbar spine cold pain,poor flexion and extension,and TCM secondary syndroms such as leg and knee tenderness,chills and limb cold in the Chinese and Western medicine group were lower than those of the Western medicine group,and the levels of inflammatory factors such as C-reactive protein(CRP),procalcitonin(PCT),interleukin-6(IL-6),erythrocyte subsidence rate(ESR)after treatment were lower than those of the Western medicine group.Visual analogue pain(VAS)scores at 3,7 and 14 days after treatment were lower than those of the Western medicine group,and the difference was statistically significant(P<0.05).During the follow-up period,Bath ankylosing spondylitis disease activity index(BASDAI)and Bath ankylosing spondylitis Function Index(BASFI)of the Chinese and western medicine group were lower than those of the control group,and Bath ankylosing spondylitis measurement Index(BASMI)was higher than that of the control group,with differences of statistical significance(P<0.05).Conclusion Based on the conventional Western medicine treatment for patients with ankylosing spondylitis,assisted Wenshen Jianpi Dingji decoction can further improve the clinical symptoms and signs of patients,relieve the pain of patients,control the level of inflammatory factors,improve the spinal function are positive.
作者
尹雪皎
赵霞
郭信
YIN Xue-jiao;ZHAO Xia;GUO Xin
出处
《中国疗养医学》
2023年第1期104-107,共4页
Chinese Journal of Convalescent Medicine
基金
河南省医学科技攻关项目(202011021),温肾健脾定脊汤在强直性脊柱炎患者治疗中的应用研究。
关键词
强直性脊柱炎
温肾健脾定脊汤
炎症因子
脊柱功能
药物不良反应
Ankylosing spondylitis
Wenshen Jianpi Dingji decoction
Inflammatory factor
Spinal function
Adverse drug reaction
