摘要
目的:探讨高尿酸血症(HUA)异常的影响因素,为代谢性疾病的早期干预提供参考。方法:选取2016年健康体检者70 523名。通过单因素分析、 logistic回归分析筛选HUA的相关因素。对应分析展示不同程度的尿酸与相关因素的聚集性。中介效应验证平均动脉压(MBP)在代谢指标异常和肾脏功能异常之间的介导作用。 结果:单因素分析显示,HUA与年龄、性别、职业、体重指数(BMI)、收缩压、舒张压、血尿素氮(BUN)、血肌酐、估算的肾小球滤过率(eGFR)、空腹血糖(FPG)、总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、血浆黏度(PV)均相关( P<0.001)。 Logistic回归分析显示,青年、男性、高血压、TC、TG和肌酐是HUA的危险因素,HDL-C是保护因素( P<0.001)。对应分析显示,在尿酸逐渐升高的过程中,TC最先出现异常,高的血压和TG次之,而肌酐的升高最后出现。中介效应显示,MBP对TC、TG和HDL-C致尿酸升高的中介效应分别为36.35%、12.63%和9.41%;MBP对TC、TG和HDL-C致eGFR降低的中介效应分别为30.20%、27.70%和6.13%。 结论:尿酸与血压、TC和TG呈正相关,与HDL-C负相关;TC、TG对肾功能损伤有影响,MBP在其中起中介作用。
Objective To investigate the influencing factors of hyperuricemia(HUA)and explore early intervention of metabolic diseases.Methods A total of 70523 participants were selected from the database of check-ups in 2016.Univariate analysis and logistic regression analysis were used to identify related factors of HUA.Correspondence analysis was performed for the aggregation of different levels of uric acid(UA)and related factors.The mediating effect of mean blood pressure(MBP)between abnormal metabolic indicators and abnormal renal function was tested.Results The age,sex,occupation,body mass index(BMI),systolic blood pressure,diastolic blood pressure,blood urea nitrogen(BUN),creatinine(Cr),estimated glomerular filtration rate(eGFR),fasting plasma glucose(FPG),total cholesterol(TC),triacylglycerol(TG),high density lipoprotein-cholesterol(HDL-C),low density lipoprotein-cholesterol,plasma viscosity were significantly related to HUA(P<0.001).Logistic regression analysis showed that youth,male,hypertension,TC,TG,and Cr were risk factors for HUA,while HDL-C was a protective factor for HUA(P<0.001).Correspondence analysis showed that during the gradual increase of UA,TC was the first to appear abnormal,followed by hypertension and TG,and the increase of Cr appeared last.Mediating effect showed that in changes of UA,the mediating effects of MBP on TC,TG,and HDL-C were 36.35%,12.63%,and 9.41%,respectively.In changes of eGFR,the mediating effects of MBP on TC,TG and HDL-C were 30.20%,27.70%,and 6.13%,respectively.Conclusions UA is positively correlated with blood pressure,TC,and TG,and inversely with HDL-C.TC and TG have an impact on renal impairment,in which MBP plays a mediating role.
作者
卓琳
陈思婷
高以焕
路航
汪秀英
卓朗
崔景秋
Zhuo Lin;Chen Siting;Gao Yihuan;Lu Hang;Wang Xiuying;Zhuo Lang;Cui Jingqiu(Department of Endocrinology and Metabolism,Tianjin Medical University General Hospital,Tianjin 300052,China;School of Management,Xuzhou Medical University,Xuzhou 221004,China;School of Public Health,Xuzhou Medical University,Xuzhou 221004,China;Department of Nephrology,Xuzhou Central Hospital,Xuzhou 221009,China)
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
2022年第10期880-886,共7页
Chinese Journal of Endocrinology and Metabolism
基金
国家自然科学基金(82070854)。
