摘要
溃疡性结肠炎的发病率逐年增加,但发病机制仍未完全明朗,广大学者分别从遗传因素、环境因素、肠道微生态失衡、肠黏膜屏障紊乱、异常免疫应答和线粒体病等方面进行研究,为进一步了解溃疡性结肠炎可能存在的发病机理,现将其研究进展进行综述,以期更好地指导临床用药,同时为进一步研究其发病机制提供新思路。
The incidence of ulcerative colitis is increasing year by year,yet the pathogenesis is still not clear.Many scholars have studied the genetic factors,environmental factors,intestinal microecological imbalance,intestinal mucosal barrier disorder,abnormal immune response and mitochondrial diseases,and abundant achievements have been made.In order to further understand the possible pathogenesis of ulcerative colitis,this paper reviews its research progress,in order to better guide clinical medication,and provide new ideas for further study of its pathogenesis.
作者
谢晶日
陈善涛
刘芝伟
XIE Jing‐ri;CHEN Shan‐tao;LIU Zhi‐wei(The First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine,Harbin 150040,China;Heilongjiang University of Traditional Chinese Medicine,Harbin 150006,China)
出处
《海南医学院学报》
CAS
2022年第23期1835-1840,共6页
Journal of Hainan Medical University
基金
国家中医药管理局全国名老中医药专家传承工作室建设项目(国中医药人教函〔2016〕42号)。
关键词
溃疡性结肠炎
发病机制
遗传
环境
肠道微生态
肠黏膜屏障
免疫应答
线粒体病
Ulcerative colitis
Pathogenesis
Heredity
Environment
Intestinal microecology
Intestinal mucosal barrier
Immune response
Mitochondrial disease
