晚期非小细胞肺癌患者化疗效果与C反应蛋白水平升高的危险因素分析被引量：2

Analysis of the effect of chemotherapy and the risk factors of elevated C-reactive protein level in patients with advanced non-small cell lung cancer

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摘要目的探讨晚期非小细胞肺癌患者化疗效果与C反应蛋白(CRP)水平升高的危险因素。方法回顾性分析2017年10月至2021年10月的广东省农垦中心医院的60例接受AP、DP方案化疗的晚期非小细胞肺癌患者的临床资料,治疗前后检测CRP,治疗结束后进行影像学检查,评估临床疗效后,分析治疗后的CRP表达水平及影响CRP的相关因素。结果患者治疗前CRP为(83.21±6.21)mg/L,经治疗后,CRP为(54.12±3.21)mg/L。单因素分析结果显示,晚期非小细胞肺癌患者CRP水平与原发灶大小(<5 cm、≥5 cm)、转移灶数目(≤3个、>3个)、美国东部肿瘤协作组(ECOG)分级有关(P<0.05)。采用logistic回归模型进行多因素分析结果显示,ECOG分级>1级(β=1.261,OR=5.343,95%CI=2.174),原发灶大小≥5 cm(β=1.173,OR=12.397,95%CI=2.164),转移灶数目>3个(β=1.291,OR=8.104,95%CI=18.635)是影响晚期非小细胞肺癌患者CRP水平的独立危险因素(P<0.05)。结论ECOG分级>1级、原发灶大小≥5 cm、转移灶数目>3个是影响晚期非小细胞肺癌患者CRP水平的独立危险因素。 Objective To explore the effect of chemotherapy and the risk factors of elevated C-reactive protein(CRP)level in patients with advanced non-small cell lung cancer.Methods The clinical data of 60 patients with advanced non-small cell lung cancer who received AP and DP chemotherapy in Guangdong Agricultural Reclamation Central Hospital from October 2017 to October 2021 were retrospectively analyzed.CRP was detected before and after treatment.After treatment,imaging examination was performed.After evaluation of clinical efficacy,the expression level of CRP and related factors affecting CRP were analyzed.Results Before treatment,CRP was(83.21±6.21)mg/L,after treatment,CRP was(54.12±3.21)mg/L.The results of univariate analysis showed that the CRP level of patients with advanced non-small cell lung cancer was related to the size of primary foci(<5 cm,≥5 cm),the number of metastatic foci(≤3,>3),and the score of the Eastern Cooperative Oncology Group(ECOG)(P<0.05).The results of multivariate analysis by logistic regression model showed that(β=1.261,OR=5.343,95%CI=2.174),and the size of the primary lesion≥5 cm(β=1.173,OR=12.397,95%CI=2.164),and the number of metastases>3(β=1.291,OR=8.104,95%CI=18.635)were independent risk factors for CRP level in patients with advanced non-small cell lung cancer(P<0.05).Conclusion High ECoG grade,primary lesion size≥5 cm and number of metastatic lesions>3 are independent risk factors for CRP level in patients with advanced non-small cell lung cancer.

作者周素丽 ZHOU Suli(No.5 District of Department of Oncology,Guangdong Agricultural Reclamation Central Hospital,Guangdong Province,Zhanjiang524000,China)

机构地区广东省农垦中心医院肿瘤内科五区

出处《中国当代医药》 CAS 2022年第33期73-75,79,共4页 China Modern Medicine

基金广东省湛江市科技计划项目(2021B01109)。

关键词非小细胞肺癌化疗疗效 C反应蛋白 Non-small cell lung cancer Chemotherapy Curative effect C-reactive protein

分类号 R734.2 [医药卫生—肿瘤]