摘要
目的分析肠内营养对肝癌患者接受动脉化疗栓塞(TACE)术后营养指标、免疫功能及肝功能的影响。方法对南阳市第一人民医院2020年7月至2021年12月接受TACE的82例肝癌患者的临床资料进行分析。根据患者接受的营养支持方法分为观察组(43例)和对照组(39例)。对照组术后接受传统方式进食(流食、半流食),观察组术后接受肠内营养支持。观察两组患者术前及术后各时点营养指标、免疫功能与肝功能水平。结果术后两组血清总蛋白(TP)、人血清白蛋白(HSA)呈上升趋势,天冬氨酸转氨酶(AST)、丙氨酸转氨酶(ALT)、直接胆红素(DBIL)、间接胆红素(IBIL)呈下降趋势(P<0.05)。术后3、5 d观察组TP、HSA水平高于对照组,AST、ALT、DBIL、IBIL水平低于对照组(P<0.05)。两组CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)水平术后呈上升趋势,CD8^(+)水平术后呈下降趋势。术后各时点观察组CD3^(+)、CD4^(+)、CD8^(+)水平高于对照组(P<0.05),CD4^(+)/CD8^(+)水平低于对照组(P<0.05)。结论肠内营养支持可促进经肝癌TACE治疗患者的营养功能、免疫功能,并能促进肝功能的恢复。
Objective To analyze the effect of enteral nutrition on nutritional index,immune function and liver function in patients with liver cancer after transcatheter arterial chemoembolization(TACE).Methods The clinical data of 82 patients with liver cancer who received TACE in Nanyang First People’s Hospital from July 2020 to December 2021 were analyzed.The patients were divided into observation group(43 cases)and control group(39 cases)according to the nutritional support methods.The control group received traditional food(liquid food,semi liquid food)after operation,and the observation group received enteral nutrition support.The nutritional indexes,immune function and liver function of the two groups were observed before and after operation.Results After operation,serum total protein(TP)and human serum albumin(HSA)showed an upward trend,while aspartate aminotransferase(AST),alanine aminotransferase(ALT),direct bilirubin(DBIL)and indirect bilirubin(IBIL)showed a downward trend(P<0.05).The levels of TP and HSA in observation group were higher than those in control group 3 and 5 days after operation,while the levels of AST,ALT,DBIL and IBIL in observation group were lower than those in control group(P<0.05).After surgery,the levels of CD3^(+),CD4^(+)and CD4^(+)/CD8^(+)in the two groups showed an upward trend,while the levels of CD8^(+)showed a downward trend.At each time point after operation,the levels of CD3^(+),CD4^(+)and CD8^(+)in observation group were higher than those in control group(P<0.05),while the levels of CD4^(+)/CD8^(+)were lower than those in control group(P<0.05).Conclusion Enteral nutrition support can promote the nutritional function,immune function and recovery of liver function in patients with liver cancer treated with TACE.
作者
于艳
史代萌
曹立颖
YU Yan;SHI Daimeng;CAO Liying(Hepatobiliary Disease Diagnosis and Treatment Center,Nanyang First People’s Hospital,Nanyang 473000,China)
出处
《河南医学研究》
CAS
2022年第22期4139-4144,共6页
Henan Medical Research
关键词
肠内营养支持
肝癌
动脉化疗栓塞术
营养指标
免疫功能
enteral nutrition support
liver cancer
arterial chemoembolization
nutritional indicator
immunity
