摘要
目的 探讨二巯丙磺酸钠对慢性汞中毒患者的临床疗效以及对血清指标数据的干预作用。方法 根据随机化要求,选择2012年3月至2022年3月在山东省职业卫生与职业病防治研究院接受治疗的50例慢性汞中毒患者作为研究对象,按照双盲对照原则分为观察组和对照组。对照组患者给予二巯丁二酸胶囊口服,观察组患者二巯基丙磺酸钠注射液肌内注射,观察两组患者临床疗效,尿汞值测定、血清细胞因子指标的评定,对比两组患者在治疗期间的不良事件。结果 观察组患者的临床总有效率为100.00%,显著比对照组的84.00%要高,存在统计学差别(P <0.05)。在治疗之前,两组患者的尿汞值经过比较发现不存在统计学方面的差别(P> 0.05),在治疗了1个疗程以及2个疗程之后,观察组患者的尿汞水平比对照组显著下降了,存在统计学方面差别(均P <0.05)。治疗之前,两组患者的血清sIL-2R、IL-6、TNF-α等指标的数据不存在统计学的差异(均P> 0.05),在治疗了2个疗程以后,两组患者以上数据均显著降低了,而且观察组指标显著低于了对照组的指标(均P <0.05)。治疗之前,两组患者的Scr、BUN、尿蛋白都不存在明显的差异(均P> 0.05),治疗了2个疗程之后,两组患者的各个指标都显著降低了,而且观察组比对照组低(均P <0.05)。两组患者的不良事件没有显著差异(P> 0.05)。结论 二巯基丙烷硫酸钠治疗慢性汞中毒患者中的除汞效果较佳,能够使血清中的sIL-2R、IL-6、TNF-α等指标下降,从而使肾功能得以提高。
Objective To investigate the clinical effect of sodium dimercaptopropane sulfonate in the treatment of chronic mercury poisoning and its influence on the level of serum indicators.Methods According to the randomization requirements,50 patients with chronic mercury poisoning who were treated in the hospital from March 2012 to March 2022 were selected as the research objects,and were divided into the observation group and the control group according to the double blind control principle.The patients in the control group were given dimercaptosuccinic acid capsules orally,and the patients in the observation group were given sodium dimercaptopropane sulfonate injection intramuscularly.The clinical efficacy of the patients in the two groups was observed,and the urine mercury value was determined serum cytokine levels were measured,and adverse reactions were compared between the two groups during treatment.Results The total effective rate of patients in the observation group(100.00%)was higher than that in the control group(84.00%),with a statistical difference(P<0.05).Before treatment,there was no statistical difference between the two groups in urine mercury values(P>0.05).After one course of treatment and two courses of treatment,the urine mercury levels in the observation group were lower than those in the control group,with a statistical difference(P<0.05).Before treatment,the serum sIL-2R,IL-6,TNF-αof patients in the two groups the level difference was not statistically significant(P>0.05).After two courses of treatment,the levels of all indicators of the patients in the two groups were lower than those before treatment,and the observation group was lower than the control group(P<0.05).Before treatment,the levels of Scr,BUN and urine protein in the patients in the two groups were not statistically significant(P>0.05).After two courses of treatment,the levels of all indicators of the patients in the two groups were lower than those before treatment,and the observation group was lower than the control group(P<0.05).There was no significant difference in adverse reactions between the two groups(P>0.05).Conclusion Sodium dimercaptopropane sulfonate has an ideal mercury excretion effect in the treatment of chronic mercury poisoning,and it can reduce serum sIL-2R,IL-6 and TNF-α,improve renal function.
作者
徐明
冯娜
白金
任丽萍
XU Ming;FENG Na;BAI Jin;REN Liping(Shandong Institute of Occupational Health and Occupational Disease Control,Ji'nan 250002,China)
出处
《中国医药指南》
2022年第33期1-4,共4页
Guide of China Medicine
基金
山东省医药卫生科技发展计划项目《汞通过线粒体途径诱导肾细胞凋亡相关机制的研究》(项目编号:2018WS171)。
关键词
二巯丙磺酸钠
慢性汞中毒
临床效果
血清指标水平
Sodium dimercaptopropane sulfonate
Chronic mercury poisoning
Clinical effect
Serum index level
