摘要
荜茇为胡椒科胡椒属植物荜茇Piper longum的成熟或未成熟果穗,是蒙古族医临床常用药之一。近年来,研究学者对民族药物研究逐渐深入,发现荜茇在降血脂、抗癌方面有着十分显著的疗效,其新的化学成分及药理活性相关研究也在不断更新,随之荜茇的开发应用研究得到了广泛的关注,因此建立和提高荜茇的质量评价体系是十分迫切的。该研究在对荜茇的化学成分及药理作用综合分析的基础上,结合质量标志物(Q-marker)概念,从植物亲缘关系、传统药性药效、复方配伍规律、化学成分的可测性和入血成分等几个方面对荜茇的质量标志物进行预测分析,为荜茇质量评价体系建立提供参考依据。
Piperis Longi Fructus,made from the mature and immature fruit spikes of Piper longum,is a commonly used Mongolian medicine.In recent years,researchers have gradually deepened the research on ethnic medicines and found that Piperis Longi Fructus has significant effects in adjusting blood lipids and anti-cancer.Its new chemical components and pharmacological activities are also constantly updated.Subsequently,the development and application of Piperis Longi Fructus have attracted extensive attention.Thus,it is quite urgent to establish and improve a quality evaluation system for the medicine.On the basis of summarizing the chemical components and pharmacological effects of Piperis Longi Fructus and understanding the new concept of quality marker(Q-marker),the components which can be used as its Q-markers were analyzed from the aspects of the genetic relationship,traditional medicinal effects and properties,rules of compounding and compatibility,absorbed components and testability.The research can provide reference for the establishment of a quality evaluation system for Piperis Longi Fructus.
作者
廖翠平
葛莎莎
阿拉坦朝鲁门
高雅
图雅
LIAO Cui-ping;GE Sha-sha;ARATAN Chaolumen;GAO Ya;TU Ya(Experimental Research Center,China Academy of Chinese Medical Sciences,Beijing 100700,China;Mongolian Medical College,Inner Mongolia Minzu University,Tongliao 028000,China;the Development of Chinese Medicine Research Center,China Academy of Chinese Medical Sciences,Beijing 100700,China)
出处
《中国中药杂志》
CAS
CSCD
北大核心
2022年第19期5182-5192,共11页
China Journal of Chinese Materia Medica
基金
国家自然科学基金面上项目(81274192,8227143138)
中国中医科学院科技创新工程项目(C12021A04209)
中国中医科学院医学实验中心协同创新团队项目(XTCX2021004)。
关键词
荜茇
化学成分
药理作用
质量标志物
Piperis Longi Fructus
chemical component
pharmacological effect
quality marker(Q-marker)
