期刊文献+

循环miR-361-5p、miR-223及miR-146a水平与ACS患者冠脉介入术后近期预后的关系

Relationship between the levels of circulating miR-361-5p,miR-223 and miR-146a and the short-term prognosis of patients with ACS after coronary intervention
下载PDF
导出
摘要 目的 探讨循环miR-361-5p、miR-223及miR-146a水平与急性冠状动脉综合征(ACS)患者冠脉介入术后近期预后的关系。方法 选择2020年12月至2021年12月就诊于文昌市人民医院心血管内科的196例行冠脉介入术ACS患者临床资料。所有ACS患者自出院后均随访6个月,以发生主要不良心脏事件(MACE)为终点。以ACS患者随访期间是否发生MACE分为MACE组(n=29)和未发生MACE组(n=167),比较两组临床资料,将有统计学意义的因素进行Logistic回归分析,绘制ROC曲线评估miR-361-5p、miR-223及miR-146a预测ACS患者发生MACE的效能。结果 196例ACS患者共发生MACE 29例(14.79%)。单因素结果显示,两组患者年龄、Cr、Tn I、BNP、miR-361-5p、miR-223及miR-146a水平比较差异有统计学意义(P<0.05)。Logistic回归分析结果显示,miR-223是影响ACS患者冠脉介入术后近期预后的保护因素(P<0.05),miR-361-5p、miR-146a是影响ACS患者冠脉介入术后近期预后的独立危险因素(P<0.05)。循环miR-361-5p、miR-223及miR-146a预测ACS患者发生MACE的曲线下面积(AUC)分别为0.763、0.701、0.794(P<0.05)。结论 循环miR-361-5p、miR-223及miR-146a水平与ACS密切相关,在预测ACS预后方面有较高的诊断价值。 Objective To investigate the relationship between the levels of circulating miR-361-5p,miR-223 and miR-146a and the short-term prognosis of patients with acute coronary syndrome(ACS)after coronary intervention. Methods The clinical data of 196 patients with ACS who underwent coronary intervention in the Department of Cardiovascular Medicine,Wenchang People’s Hospital from December 2020to December 2021 were retrospectively reviewed. All ACS patients were followed up for 6 months after discharge,with the occurrence of(major adverse cardiac events)MACE as the endpoint. ACS patients were divided into the MACE group(n=29)and the non-MACE group(n=167)according to whether MACE occurred during the follow-up period. The clinical data of the two groups were compared,and the statistically significant factors were analyzed by Logistic regression and the ROC curve was drawn to evaluate the efficacy of miR-361-5p,miR-223 and miR-146a in predicting the occurrence of MACE in ACS patients. Results There were 29cases(14.79%) of 196 ACS patients with MACE. Univariate results showed that there were significant differences in age,Cr,Tn I,BNP,miR-361-5p,miR-223 and miR-146a levels between the two groups(P<0.05). Logistic regression analysis showed that miR-223 was a protective factor affecting the short-term prognosis of patients with ACS after coronary intervention(P<0.05),and miR-361-5p and miR-146a were independent risk factors affecting the short-term prognosis of patients with ACS after coronary intervention(P<0.05). The areas under the curve(AUC)of circulating miR-361-5p,miR-223 and miR-146a for predicting MACE in ACS patients were 0.763,0.701,and 0.794,respectively(P<0.05). Conclusion The levels of circulating miR-361-5p,miR-223 and miR-146a are closely related to ACS and have high diagnostic value in predicting the prognosis of ACS.
作者 邱勋雾 李昭祺 萧少武 QIU Xunwu;LI Zhaoqi;XIAO Shaowu(Department of Cardiovascular Medicine,Wenchang People's Hospital,Wenchang,Hainan,China,571300)
出处 《分子诊断与治疗杂志》 2022年第11期1934-1937,共4页 Journal of Molecular Diagnostics and Therapy
基金 海南省卫生计生行业科研项目(18A200070)。
关键词 急性冠状动脉综合征 冠脉介入术后 miR-361-5p miR-223 MIR-146A Acute coronary syndrome After coronary intervention miR-361-5p miR-223 miR-146a
  • 相关文献

参考文献7

二级参考文献76

  • 1王小艳.急性冠脉综合征后6个月死亡和心肌梗死的预测:前瞻性的多国观察性研究(GRACE)[J].中国处方药,2006(11):25-26. 被引量:138
  • 2王小艳.早期强化他汀治疗对急性冠脉综合征的效果[J].中国处方药,2006(11):26-26. 被引量:8
  • 3Shechter M. Magnesium and cardiovascular system[J]. Magnesium Research, 2010, 23(2): 60-72.
  • 4Del Gobbo LC, Imamura F, Wu JH, et al. Circulating and dietary magnesium and risk of cardiovascular disease: a systematic review and meta-analysis of prospective studies[J]. Am J Clin Nutr, 2013, 98 (1): 160-173.
  • 5Chiuve SE, Sun Q, Curhan GC, et al. Dietary and plasma magnesium and risk of coronary heart disease among women[J]. J Am Heart Assoc, 2013, 2 (2): 1-9.
  • 6Song Y, Manson JE, Cook NR.et al. Dietary magnesium intake and risk of cardiovascular disease among women[J]. Am J Cardiol, 2005, 96 (8) :1135-1141.
  • 7Al-Delaimy WK, Rimm EB, Willett WC, et al. Magnesium intake and risk of coronary heart disease among men[J]. Journal of the American College of Nutrition, 2004, 23 (1): 63-70.
  • 8Abbott RD, Ando F, Masaki KH, et al. Dietary magnesium intake and the future risk of coronary heart disease (the Honolulu Heart Program)[J]. The American Journal of Cardiology, 2003, 92 (6) : 665-669.
  • 9Li XR, Zhang Y, Wang M, et al. The prevalence and awareness of cardiometabolic risk factors in Southern Chineses Population with coronary artery disease[J]. The Scientific World Journal, 2013, 416192: 1-9.
  • 10Gibbons RJ, Chatterjee K, Daley J, et al. ACC/AHA/ACP-ASIM guidelines for the management of patients with chronic stable angina: executive summary and recommendations. A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on Management of Patients with Chronic Stable Angina)[J]. Circulation, 1999, 99 (21): 2829-2848.

共引文献774

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部