摘要
目的:分析糖皮质激素联合序贯血液净化对蜂蜇伤合并多器官功能障碍综合征患者的治疗效果。方法:选取2020年1月-2021年8月重庆市铜梁区人民医院收治的86例蜂蜇伤合并多器官功能障碍综合征患者作为研究对象,随机分为对照组和观察组,各43例。对照组应用糖皮质激素进行治疗,观察组在对照组基础上实施序贯血液净化治疗。比较两组患者干预前后生化指标水平、并发症发生情况、住院时间及生活质量。结果:干预前,两组肿瘤坏死因子-α(TNF-α)、白细胞(WBC)、活化部分凝血活酶时间(APTT)、纤维蛋白原(PIB)、尿素氮、肌酸激酶水平比较,差异无统计学意义(P>0.05);干预后,观察组TNF-α、WBC、APTT、PIB、尿素氮、肌酸激酶水平均低于对照组,差异有统计学意义(P<0.05)。观察组并发症发生率低于对照组,差异有统计学意义(P<0.05)。观察组住院时间短于对照组,生活质量评分高于对照组,差异有统计学意义(P<0.05)。结论:对蜂蜇伤合并多器官功能障碍综合综患者实施糖皮质激素联合序贯血液净化治疗,可达到改善患者生化指标、降低并发症发生率、缩短住院时间以及提高生活质量的目的,值得临床应用并予以推广。
Objective:To analyze the treatment effect of glucocorticoid combined with sequential blood purification in the patients with bee stings and multiple organ dysfunction syndrome.Methods:A total of 86 patients with bee stings and multiple organ dysfunction syndrome admitted to the People's Hospital of Tongliang District,Chongqing from January 2020 to August 2021 were selected as the study subjects,and they were randomly divided into control group and observation group,with 43 cases in each group.The control group was treated with glucocorticoids.The observation group performed sequential blood purification treatment on the basis of the control group.The levels of biochemical indicators,the occurrence of complications,length of hospital stay and quality of life in the two groups of patients before and after intervention were compared.Results:Before the intervention,there were no significant differences in the levels of tumor necrosis factor-α(TNF-α),white blood cells(WBC),activated partial thromboplastin time(APTT),fibrinogen(PIB),urea nitrogen and creatine kinase between the two groups(P>0.05).After the intervention,the levels of TNF-α,WBC,APTT,PIB,urea nitrogen and creatine kinase in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The incidence of complications in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).The length of hospital stay in the observation group was shorter than that in the control group,and the quality of life score in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).Conclusion:The implementation of glucocorticoid combined with sequential blood purification treatment for patients with bee stings and multiple organ dysfunction syndrome can improve the biochemical indicators,reduce the incidence of complications,shorten the length of hospital stay and improve the quality of life,it deserves clinical application and promotion.
作者
王延欢
杨虎
Wang Yan-huan;Yang Hu(People's Hospital of Tongliang District,Chongqing 402560,China)
出处
《中国社区医师》
2022年第32期14-16,共3页
Chinese Community Doctors
基金
铜梁区科技局课题(编号:TL2020-20)。
关键词
蜂蜇伤
多器官功能障碍综合征
糖皮质激素
序贯血液净化
Bee stings
Multiple organ dysfunction syndrome
Glucocorticoids
Sequential blood purification
