摘要
目的:探讨在噻托溴铵的基础上加用沙美特罗替卡松在治疗慢性阻塞性肺疾病急性加重期(AECOPD)患者中的应用效果。方法:选择90例AECOPD患者为本研究的观察对象,收集时间为2019年4月—2021年3月。采用随机数字表法的方法对所有观察对象进行分组,对照组与治疗组各有45例患者。对照组患者应用噻托溴铵粉吸入剂治疗,治疗组患者联合应用噻托溴铵粉吸入剂与沙美特罗替卡松气雾剂治疗。对治疗总有效率进行比较,比较两组1s用力呼气量(FEV1)、用力肺活量(FVC)及FEV1/FVC治疗前后的变化,检测治疗前后两组血清超敏C反应蛋白(hs-CRP)、降钙素原(PCT)、白细胞介素(IL)-6水平。结果:治疗后,治疗组总有效率显著高于对照组(93.33%VS 77.78%,P<0.05)。与治疗前比较,两组FEV1、FVC、FEV1/FVC经过治疗后均显著升高(P<0.05)。与对照组治疗后比较,治疗组FEV1、FVC、FEV1/FVC指标均显著升高(P<0.05)。与治疗前比较,两组血清hs-CRP、PCT、IL-6水平经过治疗后均显著降低(P<0.05)。与对照组治疗后比较,治疗组血清hs-CRP、PCT、IL-6水平治疗后均显著降低(P<0.05)。结论:在噻托溴铵的基础上加用沙美特罗替卡松在治疗AECOPD患者取得的效果满意,患者肺功能得到改善,机体炎症反应明显降低,可以广泛推广。
Objective:To explore the effect of adding salmeterol to tiotropium bromide in the treatment of patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Method:90 patients with AECOPD were selected as the subjects of this study,and the collection time was from April 2019 to March 2021.The observation objects were divided into control group and treatment group by the method of random number table,with 45 patients in each group.Patients in the control group were treated with tiotropium bromide powder inhalation,while patients in the treatment group were treated with tiotropium bromide powder inhalation and salmeterol fluticasone aerosol.The total effective rate of treatment was compared.The changes of forced expiratory volume(FEV1)、Forced vital capacity(FVC)and FEV1/FVC before and after treatment were compared between the two groups.The levels of serum high-sensitivity C-reactive protein(hs CRP),procalcitonin(PCT)and interleukin(IL)-6 were measured before and after treatment.Result:After treatment,the total effective rate of the treatment group was significantly higher than that of the control group(93.33%VS 77.78%,P<0.05).Compared with before treatment,FEV1、FVC、FEV1/FVC in both groups increased significantly after treatment(P<0.05).Compared with the control group after treatment,FEV1、FVC、FEV1/FVC in the treatment group were significantly higher(P<0.05).After treatment,the levels of hs CRP,PCT and IL-6 in serum of the two groups were significantly lower than those before treatment(P<0.05).After treatment,the levels of hs CRP,PCT and IL-6 in serum of the treatment group decreased significantly compared with the control group(P<0.05).Conclusion:The combination of salmeterol,fluticasone and tiotropium bromide in AECOPD patients can improve lung function and reduce inflammatory reaction,thus achieving ideal clinical effect.
作者
张祝权
张家畅
聂建国
Zhang Zhuquan(Zhaoqing Gaoyao District People’s Hospital,Zhaoqing Guangdong 526000)
出处
《黑龙江医药》
CAS
2022年第6期1318-1320,共3页
Heilongjiang Medicine journal
关键词
慢性阻塞性肺疾病
急性加重
沙美特罗替卡松
噻托溴铵
Chronic obstructive pulmonary disease
Acute aggravation
Salmeterol teticasone
Tiotropium bromide
