摘要
目的观察重复经颅磁刺激(rTMS)联合利培酮治疗首发精神分裂症患者幻听症状的临床效果。方法选取2017年3月-2018年9月赣州市第三人民医院收治的有幻听症状的首发精神分裂症患者90例,根据随机数字表法分为观察组和对照组,每组45例,对照组予以利培酮治疗,观察组予以rTMS联合利培酮治疗,2组患者均治疗4周。比较2组患者的临床疗效,治疗前后阳性和阴性症状量表(PANSS)评分、听幻觉评分量表(AHRS)评分及不良反应。结果治疗4周后,观察组患者总有效率为91.11%,高于对照组的73.33%(χ^(2)=4.865,P=0.027);2组患者阳性症状、阴性症状、一般精神病理评分均低于治疗前,且观察组低于对照组(P<0.05);2组患者AHRS评分均低于治疗前,且观察组低于对照组(P<0.01);对照组与观察组患者不良反应总发生率比较差异无统计学意义(2.22%vs.6.67%,χ^(2)=0.262,P=0.609)。结论rTMS联合利培酮治疗首发精神分裂症的临床效果较好,可有效改善患者精神症状,缓解幻听症状,且安全性较高,值得应用。
Objective To observe the clinical effect of repeated transcranial magnetic stimulation(rTMS)combined with risperidone in the treatment of auditory hallucinations in patients with first-episode schizophrenia.Methods A total of 90 first-episode schizophrenia patients with auditory hallucinations admitted to the Third People′s Hospital of Ganzhou from March 2017 to September 2018 were selected.According to the random number table method,they were divided into observation group and control group,with 45 cases in each group.The control group was treated with risperidone,the observation group was treated with rTMS combined with risperidone,and both groups were treated for 4 weeks.The clinical efficacy,positive and negative syndrome scale(PANSS)score,auditory hallucinations rating scale(AHRS)score and adverse reactions were compared between the two groups before and after treatment.Results After 4 weeks of treatment,the total effective rate in the observation group was 91.11%,which was higher than 73.33%in the control group(χ^(2)=4.865,P=0.027);The positive symptoms,negative symptoms and general psychopathological scores of patients in both groups were lower than before treatment,and the observation group was lower than the control group(P<0.01);The AHRS scores of both groups were lower than before treatment,and the observation group was lower than the control group(P<0.01);There was no significant difference in the total incidence of adverse reactions between the control group and the observation group(2.22%vs.6.67%,χ^(2)=0.262,P=0.609).Conclusion The clinical effect of rTMS combined with risperidone in the treatment of first-episode schizophrenia is good,it can effectively improve the mental symptoms of patients,relieve the symptoms of auditory hallucinations,and has high safety,which is worthy of application.
作者
伍振红
WU Zhenhong(Department of Psychiatry,Third People′s Hospital of Ganzhou,Jiangxi Province,Ganzhou 341000,China)
出处
《临床合理用药杂志》
2022年第28期1-3,7,共4页
Chinese Journal of Clinical Rational Drug Use
关键词
首发精神分裂症
幻听
重复经颅磁刺激
利培酮
First-episode schizophrenia
Auditory hallucinations
Repetitive transcranial magnetic stimulation
Risperidone
