摘要
背景细胞因子水平与精神分裂症患者的症状存在相关性,同时多数精神分裂症患者在疾病进展后期会出现抑郁症状,因此精神分裂症患者伴抑郁症状与细胞因子水平的关系值得进一步探讨。目的探讨稳定期精神分裂症伴抑郁症状患者细胞因子水平及其与临床症状的相关关系。方法选择2018年5—12月安徽医科大学附属巢湖医院、合肥市第四人民医院和马鞍山市第四人民医院精神科收治的稳定期精神分裂症患者。采用卡尔加里精神分裂症抑郁量表(CDSS)评估患者的抑郁症状:以CDSS总分≥5分定义为抑郁。使用流式细胞仪多重液相蛋白定量技术检测患者血浆白介素(IL)-1β、IL-2、IL-6、IL-17A水平。采用Spearman秩相关分析和多元线性回归分析探讨稳定期精神分裂症患者细胞因子水平与抑郁的关系。结果本研究共纳入111例稳定期精神分裂症患者,抑郁发生率为28.83%(32/111)。Spearman秩相关分析显示,CDSS总分与IL-1β、IL-2及IL-17A呈正相关(rs值分别为0.507、0.466、0.374,P<0.05)。多元线性回归分析结果显示,较高水平的IL-17A是稳定期精神分裂症患者伴发抑郁的保护因素(B=-0.125,P<0.05),较长的总病程是稳定期精神分裂症患者伴发抑郁的危险因素(B=0.343,P<0.05)。结论较高水平的IL-17A及较长的总病程与稳定期精神分裂症患者伴发抑郁存在相关关系。
Background A large body of literature suggests that plasma cytokine levels are associated with symptoms in patients with schizophrenia,but the relationship of plasma cytokines with depressive symptoms,which often occur in the late stage of schizophrenia,still needs to be explored.Objective To explore the relationship between plasma cytokine levels and depressive symptoms in schizophrenic patients.Methods Patients with stable schizophrenia were selected from Department of Psychiatry of three hospitals(Chaohu Hospital Affiliated to Anhui Medical University,Hefei Fourth People's Hospital,and Maanshan Fourth People's Hospital)from May to December 2018.The Calgary Depression Scale for Schizophrenia(CDSS)was used to evaluate the depressive symptoms,and the total score of CDSS≥5 was defined as depression.The plasma levels of interleukin(IL)-1β,IL-2,IL-6 and IL-17A were detected by flowcytometry.Spearman rank correlation analysis and multiple linear regression analysis were used to analyze the relationship between plasma cytokine and depression in stable schizophrenia.Results A total of 111 patients with stable schizophrenia were included,with depression prevalence of 28.83%(32/111).Spearman rank correlation analysis showed that the total score of CDSS was positively correlated with the level of plasma IL-1β,IL-2 or IL-17A(rs=0.507,0.466,0.374,P<0.05).Multiple linear regression analysis showed that higher level of plasma IL-17A was associated with decreased of risk of depression in stable schizophrenia(B=-0.125,P<0.05),and longer duration of schizophrenia was associated with increased of risk of depression in stable schizophrenia(B=0.343,P<0.05).Conclusion Higher level of IL-17A and longer duration of schizophrenia may be correlated with depression in stable schizophrenia.
作者
孙亮
刘志伟
张雨龙
张大鹏
李文正
姚献虎
刘寰忠
SUN Liang;LIU Zhiwei;ZHANG Yulong;ZHANG Dapeng;LI Wenzheng;YAO Xianhu;LIU Huanzhong(Chaohu Hospital of Anhui Medical University,Hefei 238000,China;The Third People's Hospital of Fuyang,Fuyang 236015,China;School of Mental Health and Psychological Sciences,Anhui Medical University,Hefei 238000,China;Hefei Fourth People's Hospital,Hefei 238000,China;Maanshan Fourth People's Hospital,Maanshan 243031,China;Anhui Mental Health Center,Hefei 238000,China)
出处
《中国全科医学》
CAS
北大核心
2023年第6期687-691,698,共6页
Chinese General Practice
基金
安徽省重点研究和开发计划项目(1804h08020263)
安徽省转化医学研究院科研基金资助项目(2017zhyx17)
2019年度国家临床重点专科能力建设项目
