摘要
目的 分析绝经后原发性干燥综合征患者性激素水平变化特点及其与白细胞介素-6 (IL-6)的相关性。方法 选取2019年2月-2020年1月在中国人民解放军联勤保障部队第九〇六医院诊治的绝经后原发性干燥综合征患者47例为观察组,选取同期健康的绝经后女性47例为对照组,采用全自动化学发光免疫分析仪测定性激素六项水平,即黄体生成素(LH)、卵泡刺激素(FSH)、泌乳素(PRL)、睾酮(T)、孕酮(P)及雌二醇(E),采用酶联免疫吸附法测定血清和唾液中IL-6水平,比较两组女性上述各项指标水平,分析绝经后原发性干燥综合征患者性激素水平与IL-6的相关性。结果 观察组患者LH[(24.95±3.16)mIU/ml]、PRL[(16.12±3.08)ng/ml]水平均高于对照组[(20.06±3.72)mIU/ml、(13.89±3.64)ng/ml],T[(0.53±0.11)ng/ml]、E[(51.30±4.86)pg/ml]水平均显著低于对照组[(0.75±0.19)ng/ml、(58.67±5.52)pg/ml],差异均有统计学意义(t=6.868、3.206、6.870及6.870,均P<0.05),但两组女性FSH[观察组(45.09±6.16)mIU/ml、对照组(44.35±5.90)mIU/ml]、P[观察组(0.61±0.18)ng/ml、对照组(0.63±0.15)ng/ml]水平比较,差异均无统计学意义(t=0.595、0.585,均P>0.05)。观察组患者血清和唾液中IL-6[(79.28±15.30)ng/L、(49.16±9.38)ng/L]水平均显著高于对照组[(41.25±8.14)ng/L、(30.59±7.65)ng/L],差异均有统计学意义(t=15.044、10.518,均P<0.05)。Pearson相关分析显示,绝经后原发性干燥综合征患者LH、PRL水平与血清和唾液中IL-6水平呈显著正相关(血清r=0.354、0.417,唾液r=0.290、0.392,均P<0.05),T、E水平与血清和唾液中IL-6水平呈显著负相关(血清r=-0.524、-0.461,唾液r=-0.475、-0.395,均P<0.05),而FSH、P水平与血清和唾液中IL-6水平无显著相关性(血清r=0.021、0.030,唾液r=0.017、0.026,均P>0.05)。结论 绝经后原发性干燥综合征患者性激素水平下降更为显著,性激素水平与IL-6水平存在密切关联,共同参与了疾病的发生、发展,通过检测性激素和IL-6水平可以为绝经后原发性干燥综合征患者的诊治工作提供指导信息。
Objective To analyze the characteristics of sex hormone changes in postmenopausal patients with primary Sjogren’s syndrome and its correlation with IL-6.Methods 47 cases of postmenopausal patients with primary Sjogren’s syndrome diagnosed and treated in 906 hospital joint logistics support force from February 2019 to January 2020 were selected as the observation group, and 47 cases of healthy postmenopausal patients during the same period were selected as the control group.The six sex hormones were determined by automatic chemiluminescence immunoassay, namely luteinizing hormone(LH), follicle stimulating hormone(FSH), prolactin(PRL), testosterone(T), progesterone(P) and estradiol(E), the levels of IL-6 in serum and saliva were measured by enzyme-linked immunosorbent assay.The above indicators of two groups were compared, and the correlation between sex hormone levels and IL-6 in postmenopausal patients with primary Sjogren’s syndrome was analyzed.Results The levels of LH[(24.95±3.16)mIU/ml], PRL[(16.12±3.08)ng/ml] of the observation group were higher than that of the control group[(20.06±3.72)mIU/ml,(13.89±3.64)ng/ml], and the levels of T[(0.53±0.11)ng/ml] and E[(51.30±4.86)pg/ml]were significantly lower than those of the control group[(0.75±0.19)ng/ml,(58.67±5.52)pg/ml], the differences were statistically significant(t=6.868,3.206,6.870 and 6.870,P<0.05), but there was no statistically significant difference(t=0.595,0.585,P>0.05) in FSH[the observation group(45.09±6.16)mIU/ml, the control group(44.35±5.90)mIU/ml] and P[the observation group(0.61±0.18)ng/ml, the control group(0.63±0.15)ng/ml] levels between two groups.The IL-6[(79.28±15.30)ng/L,(49.16±9.38)ng/L] levels of serum and saliva in the observation group were significantly higher than those[(41.25±8.14)ng/L,(30.59±7.65)ng/L] in the control group, and the differences were statistically significant(t=15.044,10.518,P<0.05).Correlation analysis found that LH, PRL levels in postmenopausal patients with primary Sjogren’s syndrome were significantly positively correlated with serum and saliva IL-6 levels(serum r=0.354,0.417;saliva r=0.290,0.392, P<0.05), and T, Elevels were significantly negative correlated with serum and saliva IL-6 levels(serum r=-0.524,-0.461;saliva r=-0.475,-0.395, all P<0.05), while FSH and P levels have no significant correlation with serum and saliva IL-6 levels(serum r=0.021,0.030;saliva r=0.017,0.026, P>0.05).Conclusion The level of sex hormones in women with primary Sjogren’s syndrome after menopause has dropped more significantly, and sex hormone levels are closely related to IL-6 levels, and they are jointly involved in the occurrence and development of the disease, the detection of above indicators can be used to provide guidance information for diagnosis and treatment of primary Sjogren’s syndrome in postmenopausal patients.
作者
邓媛
黄美红
俞飞虎
简春燕
DENG Yuan;HUANG Mei-Hong;YU Fei-Hu(Department of Rheumatology and Immunology,906 Hospital Joint Logistics Support Force,Ningbo,Zhejiang 315040,China)
出处
《中国妇幼保健》
CAS
2022年第21期3906-3909,共4页
Maternal and Child Health Care of China
