摘要
视网膜新生血管(RNV)起源于视网膜血管,是许多影响视力的眼部疾病的主要病理特征之一,与脉络膜新生血管有着密不可分的联系,随着疾病进展会导致视力损伤等一系列并发症。可以利用激光诱导、手术使小鼠模型产生RNV、缺血性视网膜病变等病理表现。随着基因工程技术的不断成熟,还研发了多种RNV基因工程模型鼠。本文介绍了RNV激光诱导静脉阻塞小鼠模型、氧诱导小鼠模型、血管内皮生长因子高表达模型以及双基因敲除小鼠模型等。这些基因工程模型鼠概括了RNV在人类中的许多临床表现,不同类型小鼠模型诱导产生RNV的机制不同,可以表现出不同类型和病程的RNV症状。因此各种不同机制诱导的RNV鼠模型在RNV的病理研究中起到了一定的作用;给医务人员和相关领域研究者提供有关RNV鼠模型的介绍,从而评估此类疾病的新治疗方法,还可以为新型药物提供实验对象,为临床诊断治疗提供基础。
Retinal neovascularization(RNV)originating from retinal blood vessels is one of the main pathological features of many ocular diseases that affect vision.It is inseparably linked to choroidal neovascularization and can cause a series of complications,for instance,visual impairment as diseases progress.Pathological manifestations such as RNV and ischemic retinopathy can be constructed in mouse models by laser induction and surgery.With the continuous development of genetic engineering technology,genetic engineering has been applied in the establishment of a variety of RNV mouse models.This article introduced the RNV mouse models of laser-induced venous occlusion,oxygen-induced retinopathy,vascular endothelial growth factor high expression,and double gene knockout.These genetically engineered mouse models can have many clinical manifestations of RNV in humans.Mechanisms of inducing RNV in various types of mouse models are different,thus types and the course of RNV symptoms induced can be different.RNV mouse models induced by various mechanisms have played a role in the pathological study of RNV.This reviewed aimed to sort RNV mouse models for medical staff and researchers to evaluate new treatments for the disease,provide experimental objects for new drugs and lay a basis for clinical diagnosis and treatment.
作者
徐千惠(综述)
陈俊(审校)
邵毅(审校)
Xu Qianhui;Chen Jun;Shao Yi(Department of Ophthalmology,the First Affiliated Hospital of Nanchang University,Nanchang 330006,China)
出处
《中华实验眼科杂志》
CAS
CSCD
北大核心
2022年第10期996-998,共3页
Chinese Journal Of Experimental Ophthalmology
关键词
视网膜新生血管
基因工程
动物模型
小鼠
Retinal neovascularization
Genetic engineering
Disease models,animal
Mice
