期刊文献+

尼可地尔片治疗冠状动脉慢血流的系统评价 被引量:5

A systematic review on nicordil tablets in treatment of coronary slow flow
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摘要 目的 系统评价尼可地尔片治疗冠状动脉慢血流的有效性和安全性。方法 计算机检索Cochrane Library、PubMed、EMbase、Web of Science、中国知识资源总库(CNKI)、中国科技期刊数据库(VIP)、万方期刊数据库(WANFANG)、中国生物医学文献数据库(CBM)建库至2020年11月的文献,结合补充检索,收集所有比较西药常规联合尼可地尔片与单纯西药常规疗法的随机对照试验(RCTs),严格筛选文献并对纳入的文献进行资料提取,按照Cochrane Handbook方法评价纳入文献质量,对纳入文献的偏倚风险进行评估,应用RevMan 5.3软件进行Meta分析。结果 共纳入15个研究,共计1542例患者。Meta分析结果提示,相对于单纯西药常规治疗,尼可地尔片能显著提高冠状动脉慢血流患者的临床有效率(RR=1.43,95%CI:1.17~1.75,P=0.0004);减少胸痛发作频率(MD=-1.36,95%CI:-1.67~-1.05,P<0.00001),减少胸痛发作时间(MD=-1.31,95%CI:-1.61~-1.00,P<0.00001);增加冠状动脉(冠脉)血流速度(MD=-8.85,95%CI:-13.50~-4.21,P=0.0002);改善血清超敏C反应蛋白,降低炎症因子水平(MD=-0.92,95%CI:-1.35~-0.50,P<0.0001);改善血管内皮功能(FMD水平:MD=2.78,95%CI:2.50~3.06,P<0.00001;基础血流水平:MD=2.76,95%CI:0.05~5.46,P=0.05)。且未见明显不良反应。结论 尼可地尔片联合常规西药较单纯常规西药治疗冠脉慢血流可进一步提高疗效,且安全性较好。 Objective To systematically review the efficacy and safety of nicordil tablets in the treatment of coronary slow flow(CSF).Methods The databases of Cochrane Library,PubMed,EMbase,Web of Science,CNKI,VIP,WanFang Data and CBM were retrieved from database establishment time to Nov.2020 combined with supplement retrieving for collecting all randomized controlled trials(RCTs) about comparison between routine therapies of Western medicine combined with nicordil tablets and single routine therapies of Western medicine.The literature was strictly screened and data was extracted from included literature.The quality of included literature was reviewed according to Cochrane Handbook method.The risk of bias of included literatures was reviewed,and a Meta-analysis was conducted by using RevMan 5.3 software.Results There were totally 15 RCTs included involved 1542 patients.The results of Meta-analysis showed that nicordil tablets,compared with single routine therapies of Western medicine,improved significantly clinical effective rate in CSF patients(RR=1.43,95%CI:1.17~1.75,P=0.0004),reduced seizure frequency of chest pain(MD=-1.36,95%CI:-1.67~-1.05,P<0.00001),shortened seizure time of chest pain(MD=-1.31,95%CI:-1.61~-1.00,P<0.00001),improved coronary blood flow velocity(MD=-8.85,95%CI:-13.50~-4.21,P=0.0002),improved high sensitivity C-reactive protein(hs-CRP),decreased inflammatory cytokines(MD=-0.92,95%CI:-1.35~-0.50,P<0.0001),(MD=2.76,95%CI:0.05~5.46,P=0.05) and improved vascular endothelial function(FMD level:MD=2.78,95%CI:2.50~3.06,P<0.00001;basal blood flow level:MD=2.76,95%CI:0.05~5.46,P=0.05).There were no significant adverse reactions observed.Conclusion Nicordil tablets combined with routine therapies of Western medicine can further promote clinical efficacy with higher safety compared with single routine therapies of Western medicine.
作者 王宾 李达 闫建玲 赵国良 Wang Bin;Li Da;Yan Jianling;Zhao Guoliang(Graduate School,Shanxi University of Chinese Medicine,Jinzhong 030619,China;不详)
出处 《中国循证心血管医学杂志》 2022年第10期1173-1177,1184,共6页 Chinese Journal of Evidence-Based Cardiovascular Medicine
基金 山西省卫生健康委科研课题(2021090) 山西省高等学校科技创新项目(2020L0429) 山西中医药大学科技创新能力培育计划(2019PY-060) 山西省科技攻关项目(20140313008-12)。
关键词 冠状动脉慢血流 尼可地尔片 系统评价 META分析 Coronary slow flow Nicordil tablets Systematic review Meta-analysis
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  • 1吴立华,孙健玲,刘祎秀,张秀春,师叔田,吴迪.冠状动脉慢血流现象相关危险因素的探讨[J].中国心血管病研究,2009,7(8):592-595. 被引量:8
  • 2金文胜,潘长玉,陆菊明,智光,杨波.血糖与动脉粥样硬化的相关研究[J].中华糖尿病杂志(1006-6187),2005,13(1):19-22. 被引量:65
  • 3刘艳骄,李茵.冠心病痰浊证的病因学特点[J].新中医,1996,28(1):6-8. 被引量:14
  • 4唐容川.血证论[M].上海:上海人民出版社,1977,10..
  • 5中国血管病变早期检测技术应用指南制订委员会.中国血管病变早期检测技术应用指南(第一次报告).中国民康医学杂志,2006,18(5):323-331.
  • 6张元素.张元素医学全书.北京:中国中医药出版社2006:14,18,36.
  • 7Mangieri E,Macchiarelli G,Ciavolella M,et al.Slow coronary flow:clinical and histopathological features in patients with othwise normal epicardial coronary arteries[J].Cathet Cardiovasc Diagn,1996,37(2):375-381.
  • 8Beltrame JF,Tumer SP,Leslie SL,et al.The angiographic and clinical benefits of mibefradil in the coronary slow phenomenon[J].J Am Coll Cardiol,2004,44(2):57-62.
  • 9Celermajer DS,Sorensen KE,Gooth VM,et al.Non invasive detction of endothelial dysfunction in children and adults at risk of atherosclerosis[J].Lancet,1992,340(8828):1111-1115.
  • 10Araujo JA.Circulating microparticles from patients with coronary artery disease cause endothelial dysfunction response[J].Rev Esp Cardiol.2012,65(4):389-390.

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