摘要
目的探讨心脉隆注射液在脓毒症性心肌病治疗中的作用。方法采用随机对照、单盲法进行研究。36例诊断脓毒症性心肌病患者被随机分为对照组(n=19)和心脉隆治疗组(n=17)。2组患者均按照《2018脓毒症和脓毒性休克的管理国际指南》给予规范治疗,治疗期间利用PICCO监测仪进行血流动力学监测。试验组在规范治疗基础上加用心脉隆注射液治疗,对照组同期进行0.9%氯化钠注射液进行输注。分别于治疗开始前、开始后24 h、72 h、120 h抽取患者外周静脉血,检测肌钙蛋白I、B型脑利钠尿肽,多普勒超声心动图评价心脏功能,比较PICCO显示血流动力学血相关指标。实验数据采用SPSS 19.0统计学软件包结合相关专业进行统计学分析。结果与对照组比较,试验组肌钙蛋白I、B型脑利钠尿肽水平明显下降;左室射血分数、三尖瓣环收缩期偏移幅度、E/A升高,E峰减速时间缩短;每搏量指数、心功能指数升高,差异具有统计学意义(P<0.05)。结论心脉隆注射液对改善脓毒症性心肌病患者的心功能有一定作用。
Objective To explore the efficacy of Xinmailong injection on septic cardiomyopathy.Methods A randomized controlled,single-blind study was conducted.36 patients diagnosed with septic cardiomyopathy were randomly divided into control group(n=19)and cardiomyopathy group(n=17).All patients in the 2 groups were given standardized treatment according to the 2018 International Guidelines for the Management of Sepsis and Septic Shock,and hemodynamic monitoring was performed by PICCO monitor during treatment.The experimental group was treated with Xinmailong injection on the basis of standard treatment,and the control group was injected with 0.9%sodium chloride injection at the same time.Peripheral venous blood was extracted from patients before treatment,24 h,72 h and 120 h after treatment,respectively,to detect troponin I and B brain natriuretic peptide,Doppler echocardiography was used to evaluate cardiac function,and hemodynamic blood related indexes showed by PICCO were compared.The experimental data were statistically analyzed by SPSS 19.0 statistical software.Results Compared with the control group,the levels of Cardiac Troponin I and brain natriuretic peptide B in experimental groups were significantly decreased.Left ventricular ejection fraction(LVEF),tricuspid annular plane systolic excursion(TAPSE),E/A increased,E peak deceleration time decreased;Stroke volume index(SVI)and cardiac function index(CFI)increased,and the difference was statistically significant(P<0.05).Conclusion Xinmailong injection can improve the cardiac function of patients with septic cardiomyopathy.
作者
李文卓
杨莉
夏婧
LI Wenzhuo;YANG Li;XIA Jing(Dept.of Emergency Medicine,The 1st Affiliated Hospital of Kunming Medical University,Kunming Yunnan 650032,China)
出处
《昆明医科大学学报》
CAS
2022年第12期111-116,共6页
Journal of Kunming Medical University
基金
云南省卫生内设研究机构基金资助项目(2018NS0148)。
关键词
心脉隆注射液
脓毒症
心肌抑制
Xinmailong injection
Sepsis
Myocardial suppression
