摘要
目的探讨对急性脑出血者采用脑苷肌肽联合奥拉西坦治疗的临床效果及改善血清炎性因子水平的作用。方法选择济宁市第一人民医院2020年1—12月收治的80例急性脑出血患者为研究对象,以随机数表法分为奥拉西坦治疗的对照组(n=40)与联合脑苷肌肽治疗的观察组(n=40),比较两组临床疗效,评估患者治疗前后脑水肿、血肿量以及神经缺损(NIHSS)评分,并检测治疗前后白介素6(IL-6)、白介素10(IL-10)以及血清淀粉样蛋白(SAA)评估机体炎症反应。结果观察组总有效率高于对照组(87.50%vs 67.50%),差异有统计学意义(χ^(2)=4.588,P<0.05)。治疗后,观察组脑水肿量、脑血肿量、NIHSS评分分别为(10.24±2.06)、(9.71±2.20)mL、(9.10±2.05)分,均小于对照组(14.52±2.51)、(11.85±2.30)mL、(10.95±2.36)分,差异有统计学意义(t=8.336、4.252、3.743,P<0.05)。治疗后,观察组IL-6、SAA水平分别为(32.25±8.15)pg/mL、(25.60±6.47)mg/L,小于对照组(40.95±9.61)pg/mL、(36.11±7.64)mg/L;IL-10为(22.15±3.45)pg/mL大于对照组的(17.62±3.12)mg/L,差异有统计学意义(t=4.367、6.640、6.159,P<0.05)。结论对急性脑出血患者予脑苷肌肽联合奥拉西坦治疗能提高治疗效果,可改善脑内占位以及神经功能缺损,能够减轻机体炎症反应。
Objective To investigate the clinical effect of cerebroside carnosine combined with oxiracetam in the treatment of acute cerebral hemorrhage and the effect of improving the level of serum inflammatory factors.Methods From January to December 2020,a total of 80 patients with acute intracerebral hemorrhage were selected as the research subjects from Jining First People's Hospital Sishui District.They were divided into oxiracetam treatment control group(n=40)and cerebroside carnosine treatment observation group(n=40)by random number table method.The clinical efficacy of the two groups was compared,and the brain edema,hematoma volume and nerve defect(NIHSS)score were evaluated before and after treatment.And detect interleukin 6(IL-6),interleukin 10(IL-10)and serum amyloid(SAA)before and after treatment to evaluate the body's inflammatory response.Results The total effective rate in the observation group was higher than that in the control group(87.50%vs 67.50%),the difference was statistically significant(χ^(2)=4.588,P<0.05).After treatment,the cerebral edema,hematoma volume and NIHSS score in the observation group were(10.24±2.06)mL,(9.71±2.20)mL and(9.10±2.05)points,which were all lower than those in the control group(14.52±2.51)mL,(11.85±2.30)mL and(10.95±2.36)points,the difference was statistically significant(t=8.336,4.252,3.743,P<0.05).After treatment,the levels of IL-6 and SAA in the observation group were(32.25±8.15)pg/mL and(25.60±6.47)mg/L,respectively,which were lower than those in the control group(40.95±9.61)pg/mL and(36.11±7.64)mg/L,IL-10 was(22.15±3.45)pg/mL,which was greater than that of the control group(17.62±3.12)mg/L,the difference was statistically significant(t=4.367,6.640,6.159,P<0.05).Conclusion Cerebroside carnosine combined with oxiracetam in the treatment of acute cerebral hemorrhage can improve the therapeutic effect,improve the space-occupying and neurological deficits in the brain,and reduce the inflammatory response of the body,which is worthy of promotion.
作者
赵抗
ZHAO Kang(Department of Neurology,Jining First People's Hospital Sishui District,Jining,Shandong Province,273200 China)
出处
《世界复合医学》
2022年第10期159-163,共5页
World Journal of Complex Medicine
关键词
急性脑出血
脑苷肌肽
奥拉西坦
血清炎性因子
神经功能
脑血肿
Acute intracerebral hemorrhage
Cerebroside carnosine
Oxiracetam
Serum inflammatory factors
Neurological function
Cerebral hematoma
