摘要
目的探讨系统性红斑狼疮(SLE)患者血清Th1/Th2细胞因子及补体C3、C4的变化及意义。方法选取SLE患者129例,根据SLE疾病活动指数(SLEDAI)评分分为活动组68例(SLEDAI≥10分)和稳定组61例(SLEDAI<10分),同时选取同期健康体检者70例为对照组。比较各组血清Th1/Th2细胞因子及补体C3、C4水平,并对SLE患者C3、C4与Th1/Th2细胞因子水平进行相关性分析。结果SLE活动组IL-2、IL-4、IL-6、IL-10、TNF-α、IFN-γ水平明显高于对照组,补体C3、C4水平低于对照组(P<0.01);SLE活动组IL-6、IL-10、IFN-γ水平明显高于稳定组,补体C3、C4水平低于稳定组(P<0.01)。SLE患者C3、C4水平与IFN-γ水平以及C4水平与IL-2水平均呈负相关(P<0.05或0.01)。结论SLE患者血清中存在Th1/Th2细胞因子紊乱及补体C3、C4水平异常,监测这些指标的变化可为临床诊疗和预后提供依据。
Objective To investigate the changes of serum Th1/Th2 cytokines and complement C3 and C4 in patients with systemic lupus erythematosus(SLE)and the significance thereof.Methods A total of 129 patients with SLE were selected and divided into the Active Group(68 cases with SLEDAI score≥10)and the Stable Group(61 cases with SLEDAI score<10)according to systemic 1upus erythematosus disease activity index(SLEDAI)score,and 70 healthy persons at the same period were selected as the Control Group.The levels of serum Th1/Th2 cytokines and complement C3 and C4 in each group were compared,and the correlation between complement C3 and C4 levels and Th1/Th2 cytokine levels in SLE patients was analyzed.Results The levels of IL-2,IL-4,IL-6,IL-10,TNF-αand IFN-γin SLE Active Group were significantly higher than those in the Control Group,while the levels of complement C3 and C4 were lower than those in the Control Group(P<0.01);The levels of IL-6,IL-10 and IFN-γin SLE Active Group were significantly higher than those in the SLE Stable Group,but the levels of complement C3 and C4 were lower than those in the SLE Stable Group(P<0.01).The complement C3 and C4 levels in SLE patients were negatively correlated with IFN-γlevel,and the complement C4 level was negatively correlated with IL-2 level(P<0.05 or 0.01).Conclusion There are disorders of Th1/Th2 cytokines and abnormal levels of complement C3 and C4 in SLE patients.Monitoring the changes of these indicators can provide a basis for clinical diagnosis,treatment and prognosis.
作者
吴伯艳
陈建安
何永明
WU Bo-yan;CHEN Jian-an;HE Yong-ming(Dongguan Tungwah Hospital,Dongguan 523110,China)
出处
《广东医科大学学报》
2022年第6期664-666,共3页
Journal of Guangdong Medical University
