摘要
目的 探讨阿替普酶溶栓联合奥拉西坦治疗缺血性小卒中(MIS)的临床疗效。方法 选取医院2017年1月至2021年12月收治的MIS患者102例,按随机数字表法分为观察组和对照组,各51例。两组患者均予阿司匹林肠溶片口服,观察组患者加予注射用阿替普酶溶栓联合注射用奥拉西坦静脉滴注。结果 观察组治疗有效率为88.24%,明显高于对照组的70.59%(P <0.05);两组早期神经功能恶化发生率无显著差异(3.92%比13.73%,P> 0.05)。观察组患者治疗后的蒙特利尔认知量表总评分明显高于对照组,美国国立卫生研究院卒中量表评分明显低于对照组(P <0.05);血浆黏度、血小板聚集率、全血黏度(高切、低切)均明显低于对照组(P <0.05);血清C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素6(IL-6)水平均明显低于对照组(P <0.05)。观察组与对照组不良反应发生率相当(11.76%比5.88%,P> 0.05)。结论 阿替普酶溶栓联合奥拉西坦治疗MIS,能有效改善患者血液流变学及炎性因子水平。
Objective To investigate the clinical efficacy of alteplase thrombolysis combined with oxiracetam in the treatment of minor ischemic stroke(MIS).Methods A total of 102 patients with MIS admitted to the hospital from January 2017 to December2021 were selected and divided into the observation group and the control group by the random number table method,with 51 cases in each group. The patients in the two groups were given Aspirin Enteric-Coated Tablets orally,on this basis,the patients in the observation group were given thrombolysis of Alteplase Injection combined with an intravenous drip of Oxiracetam Injection.Results The effective rate in the observation group was 88. 24%,which was significantly higher than 70. 59% in the control group(P < 0. 05). There was no significant difference between the two groups in the incidence of early neurological deterioration(3. 92% vs. 13. 73%,P > 0. 05). After treatment,the total score of the Montreal Cognitive Scale(MoCA) in the observation group was significantly higher than that in the control group,while the score of the National Institutes of Health Stroke Scale(NIHSS) in the observation group was significantly lower than that in the control group(P < 0. 05). The plasma viscosity,platelet aggregation rate and whole blood viscosity(high-shear rate and low-shear rate) in the observation group were significantly lower than those in the control group(P < 0. 05). The levels of serum C-reactive protein(CRP),tumor necrosis factor-α(TNF-α) and interleukin-6(IL-6) in the observation group were significantly lower than those in the control group(P < 0. 05). The incidence of adverse drug reactions in the observation group was similar to that in the control group(11. 76% vs. 5. 88%,P > 0. 05).Conclusion Alteplase thrombolysis combined with oxiracetam in the treatment of MIS can effectively improve the level of hemorheology and inflammatory factors.
作者
庄俊鸿
夏鹰
杨国帅
ZHUANG Junhong;XIA Ying;YANG Guoshuai(Haikou Hospital Affiliated to Xiangya Medical College,Central South University,Haikou-,Hainan,China 570208)
出处
《中国药业》
CAS
2022年第24期89-92,共4页
China Pharmaceuticals
基金
海南省卫生健康行业科研项目(20A200077)。
