摘要
目的观察腹腔镜手术联合促性腺激素释放激素激动剂(GnRH-a)治疗子宫腺肌病的效果。方法102例子宫腺肌病患者,通过随机数字表法分为对照组和观察组,每组51例。对照组采用腹腔镜手术治疗,观察组实施腹腔镜手术联合GnRH-a治疗。比较两组患者治疗前后子宫体积、月经量、痛经程度、血红蛋白水平以及复发率、妊娠率。结果治疗后,两组患者子宫体积、月经量均小于治疗前,且观察组患者的子宫体积(106.53±8.09)cm3、月经量(94.28±8.77)ml均小于对照组的(110.61±8.23)cm3、(100.54±10.26)ml,差异均具有统计学意义(P<0.05)。治疗后,两组患者痛经视觉模拟评分法(VAS)评分均低于治疗前,且观察组患者的VAS评分(1.78±0.45)分低于对照组的(2.11±0.53)分,差异具有统计学意义(P<0.05)。治疗后,两组患者血红蛋白水平高于治疗前,且观察组患者血红蛋白(11.23±1.11)g/dl高于对照组的(10.54±1.53)g/dl,差异均具有统计学意义(P<0.05)。观察组复发率3.92%低于对照组的19.61%,妊娠率68.63%高于对照组的47.06%,差异均具有统计学意义(P<0.05)。结论在子宫腺肌病中应用腹腔镜手术+GnRH-a治疗,能够有效缩小子宫体积,减少月经量,减轻患者的疼痛程度,血红蛋白水平显著提高,提高妊娠率,减少复发情况。
Objective To observe the effect of laparoscopic surgery combined with gonadotropinreleasing hormone agonist(GnRH-a)in the treatment of adenomyosis.Methods A total of 102 patients with adenomyosis were divided into a control group and an observation group by random numerical table,with 51 cases in each group.The control group was treated by laparoscopic surgery,and the observation group was treated by laparoscopic surgery combined with GnRH-a.The uterine volume,menstrual volume,dysmenorrhea degree,and hemoglobin level before and after treatment,recurrence rate and pregnancy rates were compared between the two groups.Results After treatment,the uterine volume and menstrual volume in both groups were smaller than those before treatment in this group;the uterine volume(106.53±8.09)cm3 and menstrual volume(94.28±8.77)ml in the observation group were smaller than(110.61±8.23)cm3 and(100.54±10.26)ml in the control group;the differences were all statistically significant(P<0.05).After treatment,the visual analogue scale(VAS)scores in both groups were lower than those before treatment in this group,and the VAS score(1.78±0.45)points in the observation group was lower than(2.11±0.53)points in the control group,and the differences were all statistically significant(P<0.05).After treatment,the hemoglobin level in both groups was higher than that before treatment in this group;the hemoglobin(11.23±1.11)g/dl in the observation group was higher than(10.54±1.53)g/dl in the control group;the differences were all statistically significant(P<0.05).The recurrence rate 3.92%in the observation group was lower than 19.61%in the control group,and the pregnancy rate 68.63%was higher than 47.06%in the control group;the differences were all statistically significant(P<0.05).Conclusion The application of laparoscopic surgery+GNRH-A in the treatment of adenomyosis can effectively reduce uterine volume,reduce menstrual volume,reduce pain of patients,significantly increase hemoglobin level,improve pregnancy rate,and reduce recurrence.
作者
高怡
高铭君
GAO Yi;GAO Ming-jun(Obstetrics Department,Dalian Maternal and Child Health Hospital,Dalian 116021,China)
出处
《中国现代药物应用》
2022年第22期36-39,共4页
Chinese Journal of Modern Drug Application
