期刊文献+

The anti-cancerous mechanism of licochalcone A on human hepatoma cell HepG2 based on the miRNA omics 被引量:1

下载PDF
导出
摘要 To explore the function of licochalcone A as an anticancer phytochemical on HepG2 cells and investigate its potential mechanisms,we analyzed the microRNAs(miRNAs)expression profile of HepG2 cells in response to licochalcone A(70μmol/L)in vitro.102 dysregulated miRNAs were detected,and SP1 was expected as the transcription factor that regulates the functions of most screened miRNAs.A sum of 431 targets,the overlap of predicted mRNAs from TargetScan,miRDB,and miRtarbase were detected as the targets for these dysregulated miRNAs.FoxO signaling pathway was the hub pathway for the targets.A protein-protein interaction network was structured on the STRING platform to discover the hub genes.Among them,PIK3R1,CDC42,ESR1,SMAD4,SUMO1,KRAS,AGO1,etc.were screened out.Afterwards,the miRNA-target networks were established to screen key dysregulated miRNAs.Two key miRNAs(hsa-miR-133b and hsa-miR-145-5p)were filtered.Finally,the miRNA-target-transcription factor networks were constructed for these key miRNAs.The networks for these key miRNAs included three and two transcription factors,respectively.These identified miRNAs,transcription factors,targets,and regulatory networks may offer hints to understand the molecular mechanism of licochalcone A as a natural anticarcinogen.
出处 《Food Science and Human Wellness》 SCIE CSCD 2023年第4期1136-1148,共13页 食品科学与人类健康(英文)
基金 supported by the Hefei University Scientific Research and Development Fund(20ZR09ZDB) the talent fund of Hefei University(20RC48) the University Natural Sciences Research Project of Anhui Province(KJ2021A1009) the Major Projects of Science and Technology in Anhui Province(201903a06020021,202004a06020042,202004a06020052,201904a06020008) the National Natural Science Foundation of China(31850410476).
  • 相关文献

参考文献2

共引文献5

同被引文献6

引证文献1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部