摘要
目的:探讨降钙素原(PCT)、D-二聚体(D-D)、红细胞分布宽度(RDW)预测急性胰腺炎严重程度的临床意义。方法:对2019年5月-2021年7月厦门大学附属第一医院收治的152例急性胰腺炎(AP)住院患者(观察组)的临床资料进行回顾性分析,同时选取同期在本院进行健康体检者100例为对照组。急性胰腺炎患者根据疾病严重程度可为轻症组73例,中度重症组50例,重症组29例。比较观察组和对照组及轻症组、中度重症组、重症组PCT、D-D和RDW水平,并绘制PCT、D-D和RDW及其联合检测在AP患者严重程度的预测判断ROC曲线,进行二元Logistic回归分析。结果:观察组PCT、D-D和RDW水平与对照组相比,差异均有统计学意义(P<0.05);重症组PCT、D-D与轻度组及中度重症组比较,差异均有统计学意义(P<0.05)。做鉴别AP轻症和中度重症及重症患者的ROC曲线,PCT、D-D、RDW的AUC分别为0.778、0.765、0.609,均低于三者联合检测的0.815(P<0.05)。影响严重程度的Logistic回归分析显示PCT是影响AP严重程度的独立影响因素(P<0.05)。结论:PCT、D-D是早期预测急性胰腺炎严重程度的较理想生物学指标,三者联合检测效果更好。
Objective:To investigate the clinical significance of procalcitonin(PCT),D-dimer(D-D)and red blood cell distribution width(RDW)in predicting the severity of acute pancreatitis.Method:A retrospective analysis was conducted on 152 hospitalized patients with acute pancreatitis(AP)admitted to the First Affiliated Hospital of Xiamen University from May 2019 to July 2021,and 100 healthy people who underwent physical examination in hospital during the same period were selected as the control group.Acute pancreatitis can be divided into mild group(n=73),moderate severe group(n=50)and severe group(n=29)according to its severity.The PCT,D-D and RDW of patients in the observation group and the control group were retrospectively analyzed.The changes of the three indexes in each group were observed and compared.The ROC curve of PCT,D-D and RDW and their combined detection in predicting the severity of acute pancreatitis was drawn,and Binary Logistic regression were also performed.Result:Compared with the control group,the levels of PCT,D-D and RDW in the observation group were significantly different(P<0.05),there were significant differences in PCT and D-D between severe group and moderate severe group and mild group(P<0.05).According to the ROC curve for differentiating mild,moderate and severe AP patients,the AUC of PCT,D-D and RDW were 0.778,0.765 and 0.609 respectively,which were lower than 0.815 of the combined detection of the three(P<0.05).Logistic regression analysis showed that PCT was independent factors affecting the severity of AP(P<0.05).Conclusion:PCT and D-D are ideal biological indicators for early prediction of the severity of acute pancreatitis,and the combined detection effect of the three is better.
作者
曾秀雅
练明建
任小英
彭友缘
ZENG Xiuya;LIAN Mingjian;REN Xiaoying;PENG Youyuan(The First Affiliated Hospital of Xiamen University,Xiamen 361000,China;不详)
出处
《中外医学研究》
2022年第35期67-70,共4页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
降钙素原
D-二聚体
红细胞分布宽度
急性胰腺炎
严重程度
Procalcitonin
D-dimer
Red blood cell distribution width
Acute pancreatitis
Degree of severity
