摘要
目的基于隐结构模型法探讨辨证论治高血压伴焦虑症的用药规律,为临床辨证及用药提供依据。方法通过统一制订的临床信息采集表收集2018年1月至2020年8月河南省中医药研究院附属医院和河南省人民医院高血压科门诊或住院的180例高血压伴焦虑症患者,运用Lantern 5.0软件以症状和中药为要素构建高血压伴焦虑症的隐结构模型,进行隐类诠释,并运用SAS 10.0软件对药-药、药-症进行关联规则挖掘。结果归纳总结出高血压伴焦虑症的6个常见证型,分别为阴虚阳亢证、肝郁脾虚证、痰浊内蕴证、心脾两虚证、肾阴亏虚证、气滞血瘀证。常用药物为茯苓、天麻、陈皮、炙甘草、半夏、当归、白术、柴胡、川芎、黄芩、炒酸枣仁、白芍、钩藤、栀子、党参等。常用方剂为天麻钩藤饮、酸枣仁汤、二陈汤、柴芩汤、杞菊地黄汤、柴胡疏肝散等。结论高血压伴焦虑症患者多为痰浊内蕴证,治疗结合疏肝理气、滋补肝肾、活血化瘀、养心安神等辨证论治;用药以健脾化痰为本,理气、活血、滋阴、安神为标。
Objective To explore the rule of medication based on syndrome differentiation in treating hypertension with anxious neurosis based on the implicit structure model,and to provide evidence for clinical syndrome differentiation and medication.Methods A total of 180 patients with hypertension with anxious neurosis who were outpatients or inpatients in the Department of Hypertension,the Affiliated Hospital of Henan Academy of Traditional Chinese Medicine and Henan Provincial People’s Hospital from January 2018 to August 2020 were collected through a unified clinical information collection table.The implicit structure model of Lantern 5.0 was constructed with symptoms and Chinese medicine as the factors,and implicit interpretation was carried out,and SAS 10.0 was used to mine the association rules of drug-drug and drug-symptom.Results Six common witness types of hypertension with anxious neurosis were summarized,which were syndrome of hyperactivity of yang due to yin deficiency,syndrome of stagnation of liver qi and spleen deficiency,syndrome of phlegm-turbidity accumulated in interior,syndrome of deficiency of both heart and spleen,syndrome of kidney yin insufficiency,syndrome of qi stagnation and blood stasis.Commonly used drugs were Poria,Gastrodiae Rhizoma,Citri Reticulatae Pericarpium,Glycyrrhizae Radix Et Rhizoma Praeparata Cum Melle,Pinelliae Rhizoma,Angelicae Sinensis Radix,Atractylodis Macrocephalae Rhizoma,Bupleuri Radix,Chuanxiong Rhizoma,Scutellariae Radix,Ziziphi Spinosae Semen Tostum,Paeoniae Radix Alba,Uncariae Ramulus Cum Uncis,Gardeniae Fructus,Codonopsis Radix,etc.Commonly used formulations were Tianma Gouteng Drink,Suanzaoren Decoction,Erchen Decoction,Chaiqin Decoction,Qiju Dihuang Decoction,Chaihu Shugan Powder, etc. Conclusion The patients with hypertension with anxious neurosis are mostly phlegm and turbidities. The treatment is based on syndrome differentiation, such as dispersing liver and regulating qi, nourishing liver and kidney, promoting blood circulation for removing blood stasis, nourishing heart for tranquillization and so on. The roots are treated following the principles of invigorating the spleen and eliminating phlegm, and symptoms following the principles of regulating qi, invigorating blood, nourishing yin, and soothing the nerves.
作者
林萍
崔伟锋
庆慧
李玲
雷斯媛
LIN Ping;CUI Weifeng;QING Hui;LI Ling;LEI Siyuan(The First Clinical Medical College,Henan University of Chinese Medicine,Henan Province,Zhengzhou450046,China;Henan Academy of Traditional Chinese Medicine,Henan Province,Zhengzhou450004,China;Department of Hypertension,Henan Provincial People’s Hospital,Henan Province,Zhengzhou450003,China)
出处
《中国医药导报》
CAS
2022年第35期125-129,139,共6页
China Medical Herald
基金
国家自然科学基金资助项目(81774453)
河南省中医药科学研究专项课题(2018ZY1019)
河南省中医药拔尖人才培养项目(豫卫中医函〔2021〕15号)。
关键词
高血压伴焦虑症
隐结构模型
证候
辨证规律
关联规则
Hypertension with anxious neurosis
Implicit structure model
Syndrome
Law of syndrome differentiation
Association rules
