摘要
目的 观察杞参颗粒治疗2型糖尿病患者气阴两虚型眼干燥症的临床效果。方法 收集2020年12月至2021年5月辽宁中医药大学附属第二医院收治的2型糖尿病气阴两虚型眼干燥症患者74例(共计148眼),将其按照随机数字表法分为对照组和治疗组,每组37例。对照组予0.3%玻璃酸钠滴眼液滴眼,治疗组在此基础上予杞参颗粒口服。两组疗程均为14 d。使用Keratograph 5M眼表综合分析仪采集两组治疗前后相关指标,包括非侵入性首次泪膜破裂时间(NIBUTf)、非侵入性平均泪膜破裂时间(NIBUTav)、泪河高度(LTMH)、睑板腺缺失情况评分、眼表疾病指数(OSDI)。结果 治疗后,两组OSDI均低于治疗前,且治疗组低于对照组,差异有统计学意义(P <0.05)。治疗后,两组NIBUTf、LTMH均高于治疗前,治疗组NIBUTav高于本组治疗前,且治疗组NIBUTf、NIBUTav、LTMH高于对照组,差异有统计学意义(P <0.05)。治疗后,治疗组睑板缺失情况评分低于本组治疗前及对照组,差异有统计学意义(P <0.05)。结论 杞参颗粒治疗2型糖尿病气阴两虚型眼干燥症可有效改善患者的主要症状,值得临床推广。
Objective To observe the clinical effect of Qishen Granules in the treatment of type 2 diabetes mellitus patients with ophthalmoxerosis with deficiency of both qi and yin. Methods From December 2020 to May 2021, 74 type 2 diabetes mellitus patients with ophthalmoxerosis with deficiency of both qi and yin(148 eyes in total) admitted to the Second Affiliated Hospital of Liaoning University of Traditional Chinese Medicine were collected and divided into control group and treatment group according to the random number table method, with 37 cases in each group. The control group was given0.3% Sodium Hyaluronate Eye Drops, and the treatment group was given Qishen Granules orally on this basis. The treatment course was 14 days in both groups. Keratograph 5M ocular surface analyzer was used to measure the relevant indicators before and after treatment, including the non-invasive first tear film break-up time(NIBUTf), non-invasive average tear film break-up time(NIBUTav), lacrimal river height(LTMH), meibomian gland loss score, and ocular surface disease index(OSDI). Results After treatment, the OSDI in the two groups were lower than those before treatment, and the treatment group was lower than the control group, and the differences were statistically significant(P < 0.05). After treatment, NIBUTf and LTMH in the two groups were higher than those before treatment, NIBUTav in the treatment group was higher than that before treatment, and NIBUTf, NIBUTav, and LTMH in the treatment group were higher than those in the control group, and the differences were statistically significant(P < 0.05). After treatment, the meibomian gland loss scores in the treatment group was lower than that before treatment and the control group, and the differences were statistically significant(P < 0.05).Conclusion Qishen Granules can effectively improve the main symptoms of type 2 diabetes mellitus patients with ophthalmoxerosis with deficiency of both qi and yin, and the value of clinical promotion.
作者
鞠品
赵磊
李月鑫
左韬
JU Pin;ZHAO Lei;LI Yuexin;ZUO Tao(Graduate School,Liaoning University of Traditional Chinese Medicine,Liaoning Province,Shenyang110032,China;Department of Ophtalmology,the Second Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Liaoning Province,Shenyang110034,China)
出处
《中国医药导报》
CAS
2022年第33期96-99,共4页
China Medical Herald
基金
国家自然科学基金资助项目(82104714)。
关键词
眼干燥症
杞参颗粒
2型糖尿病
眼表综合分析仪
玻璃酸钠滴眼液
气阴两虚型
Ophthalmoxerosis
Qishen Granules
Type 2 diabetes mellitus
Ocular surface analyzer
Sodium Hyaluronate Eye Drops
Deficiency of both qi and yin
