摘要
目的 探究硝苯地平与美托洛尔联合治疗不稳定型心绞痛的临床疗效。方法 86例不稳定型心绞痛患者,依据随机数字表法分为研究组和参照组,每组43例。参照组患者接受常规治疗,研究组患者在参照组基础上接受硝苯地平联合美托洛尔治疗。比较两组患者治疗前后心功能指标[左室射血分数(LVEF)、左室舒张末期内径(LVEDD)、左室收缩末期内径(LVESD)]、心绞痛发作情况(心绞痛发作频率、心绞痛持续时间)及硝酸甘油使用频率。结果 治疗前,两组患者LVEF、LVEDD、LVESD比较差异均无统计学意义(P>0.05);治疗后,研究组患者的LVEF(50.3±5.4)%显著高于参照组的(45.3±4.7)%,LVEDD(45.8±5.0)mm与LVESD(36.7±3.2)mm显著小于参照组的(50.9±5.5)、(43.5±3.4)mm,差异有统计学意义(P<0.05)。治疗前,两组患者心绞痛发作频率、心绞痛持续时间、硝酸甘油使用频率比较差异均无统计学意义(P>0.05);治疗后,研究组患者的心绞痛发作频率(1.2±0.3)次/周、硝酸甘油使用频率(1.3±0.4)片/周均少于参照组的(4.2±0.9)次/周、(3.4±0.6)片/周,心绞痛持续时间(1.6±0.2)min/次短于参照组的(4.2±0.8)min/次,差异均有统计学意义(P<0.05)。结论 硝苯地平与美托洛尔联合治疗不稳定型心绞痛患者的效果较好,能够显著改善患者心功能指标及心绞痛发作情况,值得在临床中推广。
Objective To investigate the clinical efficacy of nifedipine combined with metoprolol in treatment of unstable angina pectoris.Methods A total of 86 patients with unstable angina were divided into a research group and a reference group according to random number table,with 43 patients in each group.Patients in the reference group received conventional treatment,and patients in the research group received nifedipine combined with metoprolol on the basis of the reference group.Both groups were compared in terms of cardiac function indexes [left ventricular ejection fraction(LVEF),left ventricular end-diastolic diameter(LVEDD),left ventricular end-systolic diameter(LVESD)],angina attacks(frequency of angina attacks,duration of angina attacks) before and after treatment,and frequency of nitroglycerin use.Results Before treatment,there were no statistically significant differences in LVEF,LVEDD and LVESD between the two groups(P>0.05).After treatment,the LVEF(50.3±5.4)% in the research group was significantly higher than(45.3±4.7)% in the reference group;the LVEDD(45.8±5.0) mm and LVESD(36.7±3.2) mm in the research group were significantly smaller than(50.9±5.5) and(43.5±3.4) mm in the reference group;the differences were all statistically significant(P0.05).After treatment,the frequency of angina attacks(1.2±0.3) times/week and the frequency of nitroglycerin use(1.3±0.4) tablets/week in the research group were less than(4.2±0.9) times/week and(3.4±0.6) tablets/week in the reference group;the duration of angina attacks(1.6±0.2) min/time in the research group was shorter than(4.2±0.8) min/time in the reference group;the differences were all statistically significant(P<0.05).Conclusion Nifedipine combined with metoprolol has a good effect in the treatment of patients with unstable angina pectoris,which can significantly improve the cardiac function index and angina attacks of patients,and it is worthy of clinical promotion.
作者
张志华
ZHANG Zhi-hua(Pulandian Gerontology Hospital,Dalian 116200,China)
出处
《中国现代药物应用》
2022年第23期86-88,共3页
Chinese Journal of Modern Drug Application
